Avridine-induced Arthritis in Rats; a T Cell-dependent Chronic Disease Influenced Both by MHC Genes and by Non-MHC Genes

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1995 Mar 1

PMID 7882557

Citations 20

Authors

C Vingsbo

R Jonsson

R Holmdahl

Affiliations

Soon will be listed here.

Abstract

Avridine is a potent synthetic adjuvant that can induce arthritis is most rat strains. The clinical appearance and histopathology of avridine-induced arthritis show great similarity to other arthritis models such as collagen-induced arthritis. In LEW and DA rats the avridine-induced arthritis is severe and long lasting. To investigate a possible genetic influence on the disease we compared LEW, DA and E3 rats, which are of different genetic origins, for their ability to develop arthritis after injection of a low dose of avridine (1.5 mg/rat). The E3 rat was shown to be resistant, whereas all of the DA rats developed arthritis. Recombinant inbred strains derived from DA and E3 parentals varied in susceptibility to avridine. Only strains sharing RT1av1 with DA developed arthritis, indicating a role for the MHC genes. The MHC association was further analysed in a series of Lewis congenic strains using the 1.5 mg avridine dose. All strains developed arthritis. LEW.1C and LEW.1W developed only acute arthritis, whereas LEW.1A, LEW, LEW.1D, LEW.1N and LEW.1F developed chronic arthritis. In particular, the LEW.1F rats developed a chronic severe arthritis of high incidence. The chronic arthritis showed an active, erosive joint inflammation several months after induction. Nude rats are resistant to avridine-induced arthritis, indicating a T cell dependence of the disease which supports the importance of MHC. However, non-MHC genes are also crucial to arthritis development. Recombinants between DA and E3, sharing RT1av1 with DA, showed either a lower incidence or a lower severity of disease than the DA rats. The E3 rat and the recombinants with RT1u were completely resistant, whereas LEW.1W, also RT1u, were highly susceptible.

Citing Articles

Advancement in nanotechnology for treatment of rheumatoid arthritis: scope and potential applications.

Rani R, Raina N, Sharma A, Kumar P, Tulli H, Gupta M Naunyn Schmiedebergs Arch Pharmacol. 2023; 396(10):2287-2310.

PMID: 37166463 DOI: 10.1007/s00210-023-02514-5.

Adjuvants- and vaccines-induced autoimmunity: animal models.

Ruiz J, Lujan L, Blank M, Shoenfeld Y Immunol Res. 2016; 65(1):55-65.

PMID: 27417999 DOI: 10.1007/s12026-016-8819-5.

Advances in research on animal models of rheumatoid arthritis.

Hu Y, Cheng W, Cai W, Yue Y, Li J, Zhang P Clin Rheumatol. 2012; 32(2):161-5.

PMID: 22885986 DOI: 10.1007/s10067-012-2041-1.

Gene expression profiling as a tool for positional cloning of genes-shortcut or the longest way round.

Rosenlof L Curr Genomics. 2009; 9(7):494-9.

PMID: 19506738 PMC: 2691671. DOI: 10.2174/138920208786241180.

Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat.

Usman Simjee S, Jawed H, Quadri J, Saeed S Arthritis Res Ther. 2007; 9(5):R91.

PMID: 17848187 PMC: 2212551. DOI: 10.1186/ar2290.

References

Yoshino S, KINNE R, Hunig T, Emmrich F . The suppressive effect of an antibody to the alpha beta cell receptor in rat adjuvant arthritis: studies on optimal treatment protocols. Autoimmunity. 1990; 7(4):255-66. DOI: 10.3109/08916939009087585. View

Whitehouse M, Orr K, BECK F, Pearson C . Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition. Immunology. 1974; 27(2):311-30. PMC: 1445566. View

Taurog J, Sandberg G, Mahowald M . The cellular basis of adjuvant arthritis. II. Characterization of the cells mediating passive transfer. Cell Immunol. 1983; 80(1):198-204. DOI: 10.1016/0008-8749(83)90106-5. View

Brideau R, CARTER P, McMaster W, Mason D, Williams A . Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur J Immunol. 1980; 10(8):609-15. DOI: 10.1002/eji.1830100807. View

Holmdahl R, Goldschmidt T, Kleinau S, Kvick C, Jonsson R . Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease. Immunology. 1992; 76(2):197-202. PMC: 1421552. View

Larsson P, Holmdahl R, Dencker L, Klareskog L . In vivo treatment with W3/13 (anti-pan T) but not with OX8 (anti-suppressor/cytotoxic T) monoclonal antibodies impedes the development of adjuvant arthritis in rats. Immunology. 1985; 56(3):383-91. PMC: 1453748. View

Robinson A, White T, Mason D . Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology. 1986; 57(2):239-47. PMC: 1453949. View

Hunig T, Wallny H, Hartley J, Lawetzky A, Tiefenthaler G . A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes. J Exp Med. 1989; 169(1):73-86. PMC: 2189202. DOI: 10.1084/jem.169.1.73. View

Holmdahl R, Rubin K, Klareskog L, Dencker L, Gustafson G, Larsson E . Appearance of different lymphoid cells in synovial tissue and in peripheral blood during the course of collagen II-induced arthritis in rats. Scand J Immunol. 1985; 21(3):197-204. DOI: 10.1111/j.1365-3083.1985.tb01421.x. View

10.

McMaster W, Williams A . Monoclonal antibodies to Ia antigens from rat thymus: cross reactions with mouse and human and use in purification of rat Ia glycoproteins. Immunol Rev. 1979; 47:117-37. DOI: 10.1111/j.1600-065x.1979.tb00291.x. View

11.

Nepom G, Erlich H . MHC class-II molecules and autoimmunity. Annu Rev Immunol. 1991; 9:493-525. DOI: 10.1146/annurev.iy.09.040191.002425. View

12.

Jacob C, Hwang F . Definition of microsatellite size variants for Tnfa and Hsp70 in autoimmune and nonautoimmune mouse strains. Immunogenetics. 1992; 36(3):182-8. DOI: 10.1007/BF00661095. View

13.

Wordsworth P, Bell J . Polygenic susceptibility in rheumatoid arthritis. Ann Rheum Dis. 1991; 50(6):343-6. PMC: 1004431. DOI: 10.1136/ard.50.6.343. View

14.

Jonsson R, Tarkowski A, Klareskog L . A demineralization procedure for immunohistopathological use. EDTA treatment preserves lymphoid cell surface antigens. J Immunol Methods. 1986; 88(1):109-14. DOI: 10.1016/0022-1759(86)90058-x. View

15.

Williams A, Galfre G, Milstein C . Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: differentiation antigens of rat lymphocytes. Cell. 1977; 12(3):663-73. DOI: 10.1016/0092-8674(77)90266-5. View

16.

Kupiec-Weglinski J, DIAMANTSTEIN T, Tilney N, Strom T . Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats. Proc Natl Acad Sci U S A. 1986; 83(8):2624-7. PMC: 323351. DOI: 10.1073/pnas.83.8.2624. View

17.

Kohashi O, Aihara K, Ozawa A, Kotani S, Azuma I . New model of a synthetic adjuvant, N-acetylmuramyl-L-alanyl-D-isoglutamine- induced arthritis: clinical and histologic studies in athymic nude and euthymic rats. Lab Invest. 1982; 47(1):27-36. View

18.

Powis S, Deverson E, Coadwell W, Ciruela A, Huskisson N, Smith H . Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. Nature. 1992; 357(6375):211-5. DOI: 10.1038/357211a0. View

19.

Holmdahl R, Andersson M, Goldschmidt T, Gustafsson K, Jansson L, Mo J . Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev. 1990; 118:193-232. DOI: 10.1111/j.1600-065x.1990.tb00817.x. View

20.

Chang Y, Pearson C, Abe C . Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: immunologic, histopathologic, and other studies. Arthritis Rheum. 1980; 23(1):62-71. DOI: 10.1002/art.1780230111. View