Cartilage-specific Autoimmunity in Animal Models and Clinical Aspects in Patients - Focus on Relapsing Polychondritis

Overview

Journal Arthritis Res

Specialty Rheumatology

Date 2002 Sep 12

PMID 12223103

Citations 4

Authors

Ann-sofie Hansson

Rikard Holmdahl

Affiliations

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Abstract

Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.

Citing Articles

Relapsing Polychondritis with Tracheobronchial Involvement: A Detailed Description of Two Pediatric Cases and Review of the Literature.

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CD10 Cells and IgM in Pathogen Response in Lumpfish () Eye Tissues.

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In search of chondrocyte-specific antigen.

Osiecka-Iwan A, Skopinski P, Radomska-Lesniewska D, Hyc A Cent Eur J Immunol. 2018; 43(2):132-138.

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Treatment of relapsing polychondritis with the TNF-alpha antagonist adalimumab.

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