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Construction of Human Y-chromosomal Haplotypes Using a New Polymorphic A to G Transition

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Journal Hum Mol Genet
Date 1994 Dec 1
PMID 7881413
Citations 33
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Abstract

We report the discovery of a polymorphic A to G transition found on the human Y chromosome by sequencing Y-specific sequence-tagged sites (STSs). It shows maximal linkage disequilibrium with a previously described Alu insertional polymorphism. We analyze further an apparently African Y chromosome which seems to have entered a Mexican Mayan population several generations ago. Using the newly discovered transition and the Y-specific polymorphic Alu insertion, we discuss how the chromosome's haplotype information might be used to answer questions of human origins and migrations.

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