New Native South American Y Chromosome Lineages

Overview

Journal J Hum Genet

Specialty Genetics

Date 2016 Apr 1

PMID 27030145

Citations 7

Authors

Marilza S Jota

Daniela R Lacerda

Jose R Sandoval

Pedro Paulo R Vieira

Dominique Ohasi

Jose E Santos-Junior

Oscar Acosta

Cinthia Cuellar

Susana Revollo

Cesar Paz-Y-Mino

Ricardo Fujita

Gustavo A Vallejo

Theodore G Schurr

Eduardo M Tarazona-Santos

Sergio Dj Pena

Qasim Ayub

Chris Tyler-Smith

Fabricio R Santos

Affiliations

Soon will be listed here.

Abstract

Many single-nucleotide polymorphisms (SNPs) in the non-recombining region of the human Y chromosome have been described in the last decade. High-coverage sequencing has helped to characterize new SNPs, which has in turn increased the level of detail in paternal phylogenies. However, these paternal lineages still provide insufficient information on population history and demography, especially for Native Americans. The present study aimed to identify informative paternal sublineages derived from the main founder lineage of the Americas-haplogroup Q-L54-in a sample of 1841 native South Americans. For this purpose, we used a Y-chromosomal genotyping multiplex platform and conventional genotyping methods to validate 34 new SNPs that were identified in the present study by sequencing, together with many Y-SNPs previously described in the literature. We updated the haplogroup Q phylogeny and identified two new Q-M3 and three new Q-L54*(xM3) sublineages defined by five informative SNPs, designated SA04, SA05, SA02, SA03 and SA29. Within the Q-M3, sublineage Q-SA04 was mostly found in individuals from ethnic groups belonging to the Tukanoan linguistic family in the northwest Amazon, whereas sublineage Q-SA05 was found in Peruvian and Bolivian Amazon ethnic groups. Within Q-L54*, the derived sublineages Q-SA03 and Q-SA02 were exclusively found among Coyaima individuals (Cariban linguistic family) from Colombia, while Q-SA29 was found only in Maxacali individuals (Jean linguistic family) from southeast Brazil. Furthermore, we validated the usefulness of several published SNPs among indigenous South Americans. This new Y chromosome haplogroup Q phylogeny offers an informative paternal genealogy to investigate the pre-Columbian history of South America.Journal of Human Genetics advance online publication, 31 March 2016; doi:10.1038/jhg.2016.26.

Citing Articles

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