The Relationship Between Motor Effects in Rats Following Acute and Chronic Haloperidol Treatment

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1994 Sep 1

PMID 7862936

Citations 4

Authors

H A Jorgensen

O A Andreassen

K Hole

Affiliations

Soon will be listed here.

Abstract

Tardive dyskinesia (TD) is a serious and sometimes irreversible side-effect to long-term neuroleptic treatment. In order to find predictors for development of TD, it would be of interest to known whether susceptibility to develop acute side-effects increases the risk of TD development. The study investigated in female Sprague-Dawley rats the relationship between haloperidol-induced acute motor effects, assessed by means of the grid test and the open field test, and the chronic motor effect assessed as vacuous chewing movements (VCM). The doses of haloperidol were 1.2, 2.4 and 4.8 mg/kg IP in the acute experiments and haloperidol decanoate 38 mg/kg per 4 weeks IM in the chronic experiment. The VCM obtained at different timepoints during the 24 weeks of chronic treatment were highly correlated. However, no correlation was found between the motor effects in the acute and the chronic experiments. The study does not indicate any connection between susceptibility to acute side-effects on neuroleptics and later development of TD.

Citing Articles

Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawal.

De Souza I, Dawson N, Clifford J, Waddington J, Meredith G Psychopharmacology (Berl). 2003; 169(1):28-34.

PMID: 12830366 DOI: 10.1007/s00213-003-1466-2.

Correlation of vacuous chewing movements with morphological changes in rats following 1-year treatment with haloperidol.

Meshul C, Andreassen O, Allen C, Jorgensen H Psychopharmacology (Berl). 1996; 125(3):238-47.

PMID: 8815959 DOI: 10.1007/BF02247334.

GM1 ganglioside attenuates the development of vacuous chewing movements induced by long-term haloperidol treatment of rats.

Andreassen O, Jorgensen H Psychopharmacology (Berl). 1994; 116(4):517-22.

PMID: 7701057 DOI: 10.1007/BF02247487.

The mitochondrial toxin 3-nitropropionic acid induces vacuous chewing movements in rats. Implications for tardive dyskinesia?.

Andreassen O, Jorgensen H Psychopharmacology (Berl). 1995; 119(4):474-6.

PMID: 7480528 DOI: 10.1007/BF02245864.

References

Barnes T, Kidger T, Gore S . Tardive dyskinesia: a 3-year follow-up study. Psychol Med. 1983; 13(1):71-81. DOI: 10.1017/s003329170005008x. View

Muscettola G, Pampallona S, Barbato G, Casiello M, Bollini P . Persistent tardive dyskinesia: demographic and pharmacological risk factors. Acta Psychiatr Scand. 1993; 87(1):29-36. DOI: 10.1111/j.1600-0447.1993.tb03326.x. View

Gunne L, Andersson U, Bondesson U, Johansson P . Spontaneous chewing movements in rats during acute and chronic antipsychotic drug administration. Pharmacol Biochem Behav. 1986; 25(4):897-901. DOI: 10.1016/0091-3057(86)90404-1. View

CRANE G . Pseudoparkinsonism and tardive dyskinesia. Arch Neurol. 1972; 27(5):426-30. DOI: 10.1001/archneur.1972.00490170058008. View

Gunne L, Growdon J, GLAESER B . Oral dyskinesia in rats following brain lesions and neuroleptic drug administration. Psychopharmacology (Berl). 1982; 77(2):134-9. DOI: 10.1007/BF00431935. View

Ahlenius S, Hillegaart V . Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: a comparison between the effects produced by pre- and post-synaptic inhibition of dopaminergic neurotransmission. Pharmacol Biochem Behav. 1986; 24(5):1409-15. DOI: 10.1016/0091-3057(86)90203-0. View

Kane J, Woerner M, Weinhold P, Wegner J, Kinon B, Borenstein M . Incidence of tardive dyskinesia: five-year data from a prospective study. Psychopharmacol Bull. 1984; 20(3):387-9. View

Kinon B, Kane J . Difference in catalepsy response in inbred rats during chronic haloperidol treatment is not predictive of the intensity of behavioral hypersensitivity which subsequently develops. Psychopharmacology (Berl). 1989; 98(4):465-71. DOI: 10.1007/BF00441943. View

Waddington J, Cross A, Gamble S, Bourne R . Spontaneous orofacial dyskinesia and dopaminergic function in rats after 6 months of neuroleptic treatment. Science. 1983; 220(4596):530-2. DOI: 10.1126/science.6132447. View

10.

Clow A, Jenner P, Marsden C . Changes in dopamine-mediated behaviour during one year's neuroleptic administration. Eur J Pharmacol. 1979; 57(4):365-75. DOI: 10.1016/0014-2999(79)90499-0. View

11.

Waddington J . Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia. Psychopharmacology (Berl). 1990; 101(4):431-47. DOI: 10.1007/BF02244220. View

12.

Rupniak N, Jenner P, Marsden C . Cholinergic manipulation of perioral behaviour induced by chronic neuroleptic administration to rats. Psychopharmacology (Berl). 1983; 79(2-3):226-30. DOI: 10.1007/BF00427817. View

13.

Iversen S, Howells R, Hughes R . Behavioral consequences of long-term treatment with neuroleptic drugs. Adv Biochem Psychopharmacol. 1980; 24:305-13. View

14.

Chouinard G, Annable L, Mercier P . A 5-year prospective longitudinal study of tardive dyskinesia: factors predicting appearance of new cases. J Clin Psychopharmacol. 1988; 8(4 Suppl):21S-26S. View

15.

Christensen A, Fjalland B, Nielsen I . On the supersensitivity of dopamine receptors, induced by neuroleptics. Psychopharmacology (Berl). 1976; 48(1):1-6. DOI: 10.1007/BF00423298. View

16.

Wolfarth S, Ossowska K . Can the supersensitivity of rodents to dopamine be regarded as a model of tardive dyskinesia?. Prog Neuropsychopharmacol Biol Psychiatry. 1989; 13(6):799-840. DOI: 10.1016/0278-5846(89)90036-5. View