The Mitochondrial Toxin 3-nitropropionic Acid Induces Vacuous Chewing Movements in Rats. Implications for Tardive Dyskinesia?

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1995 Jun 1

PMID 7480528

Citations 2

Authors

O A Andreassen

H A Jorgensen

Affiliations

Soon will be listed here.

Abstract

Rats were chronically treated for 4 weeks with three doses (4, 8, 12 mg/kg per day) of the mitochondrial toxin 3-nitropropionic acid (3-NP). The behaviour was videotaped at intervals during and after treatment, and vacuous chewing movements (VCM), a putative analogue to tardive dyskinesia (TD), as well as the general behaviour were scored. During treatment, 3-NP dose-dependently increased VCM and dose-dependently reduced motor activity, which is similar to the behavioural effect of long-term neuroleptic treatment. The results may support the hypothesis that neuroleptic-induced impairment of energy metabolism, a potential excitotoxic mechanism, is involved in the development of VCM in rats and probably TD in humans.

Citing Articles

Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection.

Lieberman J, Bymaster F, Meltzer H, Deutch A, Duncan G, Marx C Pharmacol Rev. 2008; 60(3):358-403.

PMID: 18922967 PMC: 4821196. DOI: 10.1124/pr.107.00107.

Inhibition by memantine of the development of persistent oral dyskinesias induced by long-term haloperidol treatment of rats.

Andreassen O, Aamo T, Joorgensen H Br J Pharmacol. 1996; 119(4):751-7.

PMID: 8904651 PMC: 1915756. DOI: 10.1111/j.1476-5381.1996.tb15736.x.

References

Koutouzis T, Borlongan C, Scorcia T, Creese I, Cahill D, Freeman T . Systemic 3-nitropropionic acid: long-term effects on locomotor behavior. Brain Res. 1994; 646(2):242-6. DOI: 10.1016/0006-8993(94)90085-x. View

Andreassen O, Jorgensen H . GM1 ganglioside attenuates the development of vacuous chewing movements induced by long-term haloperidol treatment of rats. Psychopharmacology (Berl). 1994; 116(4):517-22. DOI: 10.1007/BF02247487. View

Coyle J, Puttfarcken P . Oxidative stress, glutamate, and neurodegenerative disorders. Science. 1993; 262(5134):689-95. DOI: 10.1126/science.7901908. View

GALLAGHER C, KOCH J, Mann D . The effect of phenothiazine on the metabolism of liver mitochondria. Biochem Pharmacol. 1965; 14(5):789-97. DOI: 10.1016/0006-2952(65)90098-5. View

McGeer E, McGeer P . Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids. Nature. 1976; 263(5577):517-9. DOI: 10.1038/263517a0. View

Shigenaga M, Hagen T, Ames B . Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A. 1994; 91(23):10771-8. PMC: 45108. DOI: 10.1073/pnas.91.23.10771. View

Waddington J . Schizophrenia, affective psychoses, and other disorders treated with neuroleptic drugs: the enigma of tardive dyskinesia, its neurobiological determinants, and the conflict of paradigms. Int Rev Neurobiol. 1989; 31:297-353. DOI: 10.1016/s0074-7742(08)60282-2. View

Jeste D, Caligiuri M . Tardive dyskinesia. Schizophr Bull. 1993; 19(2):303-15. DOI: 10.1093/schbul/19.2.303. View

Beal M, Brouillet E, Jenkins B, Ferrante R, Kowall N, Miller J . Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J Neurosci. 1993; 13(10):4181-92. PMC: 6576392. View

10.

Meshul C, Stallbaumer R, Taylor B, Janowsky A . Haloperidol-induced morphological changes in striatum are associated with glutamate synapses. Brain Res. 1994; 648(2):181-95. DOI: 10.1016/0006-8993(94)91117-7. View

11.

Byczkowski J, Borysewicz R . The action of chlorpromazine and imipramine on rat brain mitochondria. Gen Pharmacol. 1979; 10(5):369-72. DOI: 10.1016/0306-3623(79)90072-7. View

12.

Jorgensen H, Andreassen O, Hole K . The relationship between motor effects in rats following acute and chronic haloperidol treatment. Psychopharmacology (Berl). 1994; 116(1):89-92. DOI: 10.1007/BF02244876. View

13.

Jeste D, Lohr J, Manley M . Study of neuropathologic changes in the striatum following 4, 8 and 12 months of treatment with fluphenazine in rats. Psychopharmacology (Berl). 1992; 106(2):154-60. DOI: 10.1007/BF02801966. View

14.

Yamamoto B, Cooperman M . Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. J Neurosci. 1994; 14(7):4159-66. PMC: 6577061. View

15.

Burkhardt C, Kelly J, Lim Y, Filley C, Parker Jr W . Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol. 1993; 33(5):512-7. DOI: 10.1002/ana.410330516. View