Magnetization Transfer Contrast (MTC) and MTC-subtraction: Enhancement of Cartilage Lesions and Intracartilaginous Degeneration in Vitro

Overview

Journal Skeletal Radiol

Specialties Orthopedics
Radiology

Date 1994 Oct 1

PMID 7824982

Citations 7

Authors

M Vahlensieck

F Dombrowski

C Leutner

U Wagner

M Reiser

Affiliations

Soon will be listed here.

Abstract

Human articular cartilage from 16 cadaveric or amputated knees was studied using standard magnetic resonance imaging (MRI), on-resonance magnetization transfer contrast (MTC) and MTC-subtraction MRI. Results were compared with subsequent macroscopic and histopathological findings. MTC-subtraction and T2-weighted spin-echo images visualized cartilaginous surface defects with high sensitivity and specificity. MTC and T2-weighted spin-echo images revealed intra-cartilaginous signal loss without surface defects in 80% of the cases, corresponding to an increased collagen concentration. It is concluded that MTC is sensitive to early cartilage degeneration and MTC-subtraction can be helpful in detecting cartilage defects.

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