Comparison of Microstructural and Mechanical Properties of Trabeculae in Femoral Head from Osteoporosis Patients with and Without Cartilage Lesions: a Case-control Study

Overview

Journal BMC Musculoskelet Disord

Publisher Biomed Central

Specialties Orthopedics
Physiology

Date 2015 Apr 19

PMID 25887431

Citations 6

Authors

Houchen Lv

Licheng Zhang

Fei Yang

Zhe Zhao

Qi Yao

Lihai Zhang

Peifu Tang

Affiliations

Soon will be listed here.

Abstract

Background: Degeneration of cartilage will change load distribution, affecting bone remodeling progress and trabecular structure and strength. However, in human primary osteoporosis, whether cartilage lesions would also affect properties beneath trabecular bone remains unknown. In this study, we explored the differences in local trabecular properties between osteoporosis patients with and without cartilage lesions.

Methods: Eighteen pairs of femoral heads with and without cartilage lesions in a weight-bearing area were collected from senile femoral neck fracture patients. The Mankin score and glycosaminoglycan (GAG) content were used to evaluate the severity of the cartilage lesions. Micro-CT and compression tests were used to obtain structural and mechanical characteristics of each trabecular column. Multivariate linear regression was performed to evaluate the association between mechanical parameters and the degree of cartilage lesion.

Results: In osteoporosis patients with cartilage lesions, the bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) of the trabecular column were significantly higher than that of osteoporotic control patients (all P < 0.05), while the Young's modulus was lower (P = 0.024). Multivariable linear regression indicated that in both groups, bone mineral density (BMD) significantly correlated with Young's modulus (all P < 0.05). While in patients with cartilage lesion, GAG content was also correlated with Young's modulus (standardized coefficient 0.443, P < 0.01).

Conclusions: Osteoporosis patients with cartilage lesions exhibited a weaker mechanical property of trabeculae. The intimate association of cartilage lesions and impairment of trabecular mechanical properties indicate that cartilage and trabeculae belong to an interdependent functional unit. Previously proposed adaptive mechanisms in osteoarthritis might also be applicable to the progression of osteoporosis.

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References

Kanis J, Burlet N, Cooper C, Delmas P, Reginster J, Borgstrom F . European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008; 19(4):399-428. PMC: 2613968. DOI: 10.1007/s00198-008-0560-z. View

Sun S, Ma H, Liu C, Huang C, Cheng C, Wei H . Difference in femoral head and neck material properties between osteoarthritis and osteoporosis. Clin Biomech (Bristol). 2008; 23 Suppl 1:S39-47. DOI: 10.1016/j.clinbiomech.2007.11.018. View

Cui W, Won Y, Baek M, Lee D, Chung Y, Hur J . Age-and region-dependent changes in three-dimensional microstructural properties of proximal femoral trabeculae. Osteoporos Int. 2008; 19(11):1579-87. DOI: 10.1007/s00198-008-0601-7. View

Bobinac D, Marinovic M, Bazdulj E, Cvijanovic O, Celic T, Maric I . Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis. Osteoarthritis Cartilage. 2013; 21(11):1724-30. DOI: 10.1016/j.joca.2013.06.030. View

Capuani S, Piccirilli E, Di Pietro G, Celi M, Tarantino U . Microstructural differences between osteoporotic and osteoarthritic femoral cancellous bone: an in vitro magnetic resonance micro-imaging investigation. Aging Clin Exp Res. 2013; 25 Suppl 1:S51-4. DOI: 10.1007/s40520-013-0095-9. View

Anderson D, Madigan M . Effects of age-related differences in femoral loading and bone mineral density on strains in the proximal femur during controlled walking. J Appl Biomech. 2012; 29(5):505-16. PMC: 3796161. DOI: 10.1123/jab.29.5.505. View

. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001; 285(6):785-95. DOI: 10.1001/jama.285.6.785. View

Squires G, Okouneff S, Ionescu M, Robin Poole A . The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum. 2003; 48(5):1261-70. DOI: 10.1002/art.10976. View

Antoniades L, MacGregor A, Andrew T, Spector T . Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology (Oxford). 2003; 42(6):791-6. DOI: 10.1093/rheumatology/keg227. View

10.

Mankin H, DORFMAN H, Lippiello L, Zarins A . Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971; 53(3):523-37. View

11.

Foss M, Byers P . Bone density, osteoarthrosis of the hip, and fracture of the upper end of the femur. Ann Rheum Dis. 1972; 31(4):259-64. PMC: 1005923. DOI: 10.1136/ard.31.4.259. View

12.

Pogrund H, Rutenberg M, Makin M, ROBIN G, Menczel J, Steinberg R . Osteoarthritis of the hip joint and osteoporosis: a radiological study in a random population sample in Jerusalem. Clin Orthop Relat Res. 1982; (164):130-5. View

13.

Healey J, Vigorita V, Lane J . The coexistence and characteristics of osteoarthritis and osteoporosis. J Bone Joint Surg Am. 1985; 67(4):586-92. View

14.

Farndale R, Buttle D, Barrett A . Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta. 1986; 883(2):173-7. DOI: 10.1016/0304-4165(86)90306-5. View

15.

Carter D, ORR T, Fyhrie D . Relationships between loading history and femoral cancellous bone architecture. J Biomech. 1989; 22(3):231-44. DOI: 10.1016/0021-9290(89)90091-2. View

16.

Vahlensieck M, Dombrowski F, Leutner C, Wagner U, Reiser M . Magnetization transfer contrast (MTC) and MTC-subtraction: enhancement of cartilage lesions and intracartilaginous degeneration in vitro. Skeletal Radiol. 1994; 23(7):535-9. DOI: 10.1007/BF00223085. View

17.

Li B, Aspden R . Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. J Bone Miner Res. 1997; 12(4):641-51. DOI: 10.1359/jbmr.1997.12.4.641. View

18.

Li B, Aspden R . Material properties of bone from the femoral neck and calcar femorale of patients with osteoporosis or osteoarthritis. Osteoporos Int. 1997; 7(5):450-6. DOI: 10.1007/s001980050032. View

19.

Mkukuma L, Imrie C, Skakle J, Hukins D, Aspden R . Thermal stability and structure of cancellous bone mineral from the femoral head of patients with osteoarthritis or osteoporosis. Ann Rheum Dis. 2005; 64(2):222-5. PMC: 1755354. DOI: 10.1136/ard.2004.021329. View

20.

Aurich M, Squires G, Reiner A, Mollenhauer J, Kuettner K, Robin Poole A . Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints. Arthritis Rheum. 2005; 52(1):112-9. DOI: 10.1002/art.20740. View