Clinical Implications of the Stress Response

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1995 Jan 1

PMID 7814629

Citations 51

Authors

G Minowada

W J Welch

Affiliations

Soon will be listed here.

Abstract

A field of research that began with a curious observation in Drosophila has resulted in a new understanding of how cells respond to sudden and adverse changes in their environment. In addition through the study of the structure/function of the stress proteins, especially those which function as molecular chaperones, new insights into the details by which proteins are synthesized and acquire their final biologically active conformation have been realized. Equally exciting is the progress being made as it relates the potential diagnostic and therapeutic applications of the stress-response proteins. The use of stress proteins as the next generation of vaccines and/or their use as potentially powerful adjuvants, capable of stimulating both T and B cell responses to a particular antigen of interest appear close to becoming a reality. One wonders how many more surprises are in store for us as we continue to explore this evolutionally conserved cellular stress response.

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References

Young D . Heat-shock proteins: immunity and autoimmunity. Curr Opin Immunol. 1992; 4(4):396-400. DOI: 10.1016/s0952-7915(06)80029-4. View

Young R, Elliott T . Stress proteins, infection, and immune surveillance. Cell. 1989; 59(1):5-8. DOI: 10.1016/0092-8674(89)90861-1. View

Barbe M, Tytell M, Gower D, Welch W . Hyperthermia protects against light damage in the rat retina. Science. 1988; 241(4874):1817-20. DOI: 10.1126/science.3175623. View

Ferguson A . Mucosal immunology. Immunol Today. 1990; 11(1):1-3. DOI: 10.1016/0167-5699(90)90002-q. View

Welch W . How cells respond to stress. Sci Am. 1993; 268(5):56-64. DOI: 10.1038/scientificamerican0593-56. View

Miron T, Vancompernolle K, Vandekerckhove J, Wilchek M, Geiger B . A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol. 1991; 114(2):255-61. PMC: 2289078. DOI: 10.1083/jcb.114.2.255. View

Ensgraber M, Loos M . A 66-kilodalton heat shock protein of Salmonella typhimurium is responsible for binding of the bacterium to intestinal mucus. Infect Immun. 1992; 60(8):3072-8. PMC: 257283. DOI: 10.1128/iai.60.8.3072-3078.1992. View

Delcayre C, Samuel J, Marotte F, Mercadier J, Rappaport L . Synthesis of stress proteins in rat cardiac myocytes 2-4 days after imposition of hemodynamic overload. J Clin Invest. 1988; 82(2):460-8. PMC: 303535. DOI: 10.1172/JCI113619. View

Gomez F, Gomez A, Deepe Jr G . An 80-kilodalton antigen from Histoplasma capsulatum that has homology to heat shock protein 70 induces cell-mediated immune responses and protection in mice. Infect Immun. 1992; 60(7):2565-71. PMC: 257204. DOI: 10.1128/iai.60.7.2565-2571.1992. View

10.

Barrios C, Lussow A, van Embden J, van der Zee R, Rappuoli R, Costantino P . Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guérin priming. Eur J Immunol. 1992; 22(6):1365-72. DOI: 10.1002/eji.1830220606. View

11.

Kaufman D, Clare-Salzler M, Tian J, Forsthuber T, Ting G, Robinson P . Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature. 1993; 366(6450):69-72. PMC: 8216222. DOI: 10.1038/366069a0. View

12.

Georgopoulos C, Welch W . Role of the major heat shock proteins as molecular chaperones. Annu Rev Cell Biol. 1993; 9:601-34. DOI: 10.1146/annurev.cb.09.110193.003125. View

13.

Lis J, Wu C . Protein traffic on the heat shock promoter: parking, stalling, and trucking along. Cell. 1993; 74(1):1-4. DOI: 10.1016/0092-8674(93)90286-y. View

14.

Ellis R, Van Der Vies S . Molecular chaperones. Annu Rev Biochem. 1991; 60:321-47. DOI: 10.1146/annurev.bi.60.070191.001541. View

15.

Lussow A, Barrios C, van Embden J, van der Zee R, Verdini A, Pessi A . Mycobacterial heat-shock proteins as carrier molecules. Eur J Immunol. 1991; 21(10):2297-302. DOI: 10.1002/eji.1830211002. View

16.

Yem A, Tomasselli A, Heinrikson R, Ruff V, Johnson R, Deibel Jr M . The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. J Biol Chem. 1992; 267(5):2868-71. View

17.

Welch W . Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol Rev. 1992; 72(4):1063-81. DOI: 10.1152/physrev.1992.72.4.1063. View

18.

Blander S, Horwitz M . Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' disease. J Clin Invest. 1993; 91(2):717-23. PMC: 288014. DOI: 10.1172/JCI116253. View

19.

Vass K, Berger M, Nowak Jr T, Welch W, Lassmann H . Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat. Neurosci Lett. 1989; 100(1-3):259-64. DOI: 10.1016/0304-3940(89)90695-2. View

20.

Koenig W, Lohner R, Perdrizet G, Lohner M, Schweitzer R, Lewis Jr V . Improving acute skin-flap survival through stress conditioning using heat shock and recovery. Plast Reconstr Surg. 1992; 90(4):659-64. DOI: 10.1097/00006534-199210000-00016. View