The Effect of Space and Parabolic Flight on Macrophage Hematopoiesis and Function

Overview

Journal Exp Cell Res

Specialty Cell Biology

Date 1995 Jan 1

PMID 7813616

Citations 19

Authors

J W Armstrong

R A Gerren

S K Chapes

Affiliations

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Abstract

We used weak electric fields to monitor macrophage spreading in microgravity. Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s. We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages.

Citing Articles

Omics Studies of Specialized Cells and Stem Cells under Microgravity Conditions.

Abdelfattah F, Schulz H, Wehland M, Corydon T, Sahana J, Kraus A Int J Mol Sci. 2024; 25(18).

PMID: 39337501 PMC: 11431953. DOI: 10.3390/ijms251810014.

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight.

Garcia-Medina J, Sienkiewicz K, Narayanan S, Overbey E, Grigorev K, Ryon K Precis Clin Med. 2024; 7(1):pbae007.

PMID: 38634106 PMC: 11022651. DOI: 10.1093/pcmedi/pbae007.

The Effects of Simulated Microgravity on Macrophage Phenotype.

Ludtka C, Moore E, Allen J Biomedicines. 2021; 9(9).

PMID: 34572391 PMC: 8472625. DOI: 10.3390/biomedicines9091205.

Macrophages in microgravity: the impact of space on immune cells.

Ludtka C, Silberman J, Moore E, Allen J NPJ Microgravity. 2021; 7(1):13.

PMID: 33790288 PMC: 8012370. DOI: 10.1038/s41526-021-00141-z.

The Emerging Role of Macrophages in Immune System Dysfunction under Real and Simulated Microgravity Conditions.

Sun Y, Kuang Y, Zuo Z Int J Mol Sci. 2021; 22(5).

PMID: 33652750 PMC: 7956436. DOI: 10.3390/ijms22052333.