Mechanisms of Rapid Bone Loss Following Cardiac Transplantation

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 1994 Sep 1

PMID 7812075

Citations 8

Authors

P N Sambrook

P J Kelly

D Fontana

T Nguyen

A Keogh

P Macdonald

P Spratt

J Freund

J A Eisman

Affiliations

Soon will be listed here.

Abstract

Rapid bone loss after orthoptic cardiac transplantation (OHTX) is a major problem; however, the mechanisms are poorly understood. To investigate these mechanisms we measured biochemical and hormonal indices of bone turnover serially in 25 patients (21 men, 4 women) after OHTX. Serum osteocalcin was reduced immediately post-OHTX (2.2 +/- 0.5 ng/ml) but rose significantly by 6 and 12 months (14.1 +/- 2.5 and 15.7 +/- 2.2 respectively). Bone resorption indices (urinary hydroxyproline/creatinine and calcium/creatinine ratios) were increased immediately post-OHTX but fell by 6 months. Serum testosterone was reduced in males but recovered towards normal values by 6-12 months. Regression analysis showed lumbar bone loss was predicted independently by the change in both serum osteocalcin and testosterone. The data suggest that bone loss post-OHTX is due to a combination of accelerated turnover and hypogonadism.

Citing Articles

Endocrine disorders after heart transplantation: national cohort study.

Rakusa M, Vrtovec B, Poglajen G, Janez A, Jensterle M BMC Endocr Disord. 2020; 20(1):54.

PMID: 32312324 PMC: 7171847. DOI: 10.1186/s12902-020-0533-6.

Zoledronic acid versus alendronate for the prevention of bone loss after heart or liver transplantation.

Shane E, Cohen A, Stein E, McMahon D, Zhang C, Young P J Clin Endocrinol Metab. 2012; 97(12):4481-90.

PMID: 23024190 PMC: 3591679. DOI: 10.1210/jc.2012-2804.

Vitamin D in organ transplantation.

Stein E, Shane E Osteoporos Int. 2011; 22(7):2107-18.

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Serum testosterone levels after cardiac transplantation.

Fleischer J, McMahon D, Hembree W, Addesso V, Longcope C, Shane E Transplantation. 2008; 85(6):834-9.

PMID: 18360264 PMC: 2908279. DOI: 10.1097/TP.0b013e318166ac10.

Show a heart for bones in time--fractures remain a common problem following cardiac transplantation.

Dobnig H Wien Klin Wochenschr. 2004; 116(5-6):151-4.

PMID: 15088988 DOI: 10.1007/BF03040480.

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