Osteoporosis After Solid Organ and Bone Marrow Transplantation

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2003 Aug 9

PMID 12908095

Citations 25

Authors

Adi Cohen

Elizabeth Shane

Affiliations

Soon will be listed here.

Abstract

Organ transplantation has become increasingly common as a therapy for end-stage renal, liver, cardiac and pulmonary disease. The population of patients who have survived organ transplantation has grown dramatically over the last 2 decades. Although organ transplant recipients now benefit from greatly improved survival, long-term complications of organ transplantation, such as osteoporosis, adversely affect quality of life and must be addressed. In the early post-transplantation period, the effects of high dose glucocorticoids, combined with other immunosuppressive drugs such as cycosporine A and tacrolimus, cause rapid bone loss particularly at the spine and proximal femur. In this setting, fracture incidence rates as high as 25-65% have been reported. Treatment and prevention strategies must target this early post-transplant period, as well as the patient awaiting transplantation and the long-term transplant recipient. This review will discuss the clinical features of transplantation osteoporosis, the pathophysiology of post-transplantation bone loss and prevention and therapy of this unique bone disease.

Citing Articles

Osteoporosis and Bone Fragility in Children: Diagnostic and Treatment Strategies.

Cannalire G, Biasucci G, Bertolini L, Patianna V, Petraroli M, Pilloni S J Clin Med. 2024; 13(16).

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Physical Exercise After Solid Organ Transplantation: A Cautionary Tale.

Stylemans D, Vandecruys M, Leunis S, Engelborghs S, Gargioli D, Monbaliu D Transpl Int. 2024; 37:12448.

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High risk of osteoporosis and fracture following solid organ transplantation: a population-based study.

Chen H, Lai Y, Yang Y, Gau S, Huang C, Tsai T Front Endocrinol (Lausanne). 2023; 14:1167574.

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Timing of Osteoporotic Vertebral Fractures in Lung and Heart Transplantation: A Longitudinal Study.

Caffarelli C, Tomai Pitinca M, Alessandri M, Cameli P, Bargagli E, Bennett D J Clin Med. 2020; 9(9).

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Effect of Bisphosphonates on Bone Health in Adult Renal Transplant Patients: Beyond the First Year Posttransplant-A Systematic Review and Meta-Analysis.

Lip A, Warias A, Shamseddin M, Thomson B, Wijeratne D Can J Kidney Health Dis. 2019; 6:2054358119858014.

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