Substrate Specificity of Epstein-Barr Virus Thymidine Kinase

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1994 Sep 1

PMID 7811040

Citations 14

Authors

P P TUNG

W C Summers

Affiliations

Soon will be listed here.

Abstract

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epstein-Barr virus thymidine kinase.

Citing Articles

Valganciclovir for the Suppression of Epstein-Barr Virus Replication.

Yager J, Magaret A, Kuntz S, Selke S, Huang M, Corey L J Infect Dis. 2017; 216(2):198-202.

PMID: 28838145 PMC: 5854009. DOI: 10.1093/infdis/jix263.

Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.

Coen N, Duraffour S, Topalis D, Snoeck R, Andrei G Antimicrob Agents Chemother. 2014; 58(12):7312-23.

PMID: 25267682 PMC: 4249563. DOI: 10.1128/AAC.03957-14.

Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses.

Coen N, Singh U, Vuyyuru V, van den Oord J, Balzarini J, Duraffour S J Virol. 2013; 87(7):3839-51.

PMID: 23345517 PMC: 3624198. DOI: 10.1128/JVI.03338-12.

The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.

Meng Q, Hagemeier S, Fingeroth J, Gershburg E, Pagano J, Kenney S J Virol. 2010; 84(9):4534-42.

PMID: 20181711 PMC: 2863746. DOI: 10.1128/JVI.02487-09.

Epstein-Barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles.

Gill M, Kutok J, Fingeroth J J Virol. 2007; 81(12):6523-35.

PMID: 17428875 PMC: 1900094. DOI: 10.1128/JVI.00147-07.

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