Efficacy of the Triazole D0870 in a Murine Model of Systemic Histoplasmosis

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1995 Mar 1

PMID 7793893

Citations 4

Authors

K V Clemons

D A Stevens

Affiliations

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Abstract

The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole. All regimens of D0870 (1 or 10 mg/kg of body weight given daily or 1, 10, or 100 mg/kg given every other day) and 100 mg of fluconazole per kg given daily provided complete protection from lethality. Comparison of the number of viable Histoplasma capsulatum yeasts remaining in the spleen or liver indicated that D0870 was superior to fluconazole in clearing and curing infection. D0870 was 10- to 100-fold more efficacious than fluconazole in the treatment of experimental histoplasmosis.

Citing Articles

Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.

Clemons K, Martinez M, Calderon L, Stevens D Antimicrob Agents Chemother. 2002; 46(3):922-4.

PMID: 11850289 PMC: 127511. DOI: 10.1128/AAC.46.3.922-924.2002.

Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis.

Sorensen K, Clemons K, Stevens D Mycopathologia. 2000; 146(2):53-65.

PMID: 10822504 DOI: 10.1023/a:1007081707287.

Comparison of a new triazole antifungal agent, Schering 56592, with itraconazole and amphotericin B for treatment of histoplasmosis in immunocompetent mice.

Connolly P, Wheat J, Schnizlein-Bick C, Durkin M, Kohler S, Smedema M Antimicrob Agents Chemother. 1999; 43(2):322-8.

PMID: 9925526 PMC: 89071. DOI: 10.1128/AAC.43.2.322.

Efficacy of D0870 treatment of experimental Candida vaginitis.

Fidel Jr P, Cutright J, Sobel J Antimicrob Agents Chemother. 1997; 41(7):1455-9.

PMID: 9210665 PMC: 163939. DOI: 10.1128/AAC.41.7.1455.

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