A Nonparametric Approach for Mapping Quantitative Trait Loci

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1995 Mar 1

PMID 7768449

Citations 105

Authors

L Kruglyak

E S Lander

Affiliations

Soon will be listed here.

Abstract

Genetic mapping of quantitative trait loci (QTLs) is performed typically by using a parametric approach, based on the assumption that the phenotype follows a normal distribution. Many traits of interest, however, are not normally distributed. In this paper, we present a nonparametric approach to QTL mapping applicable to any phenotypic distribution. The method is based on a statistic ZW, which generalizes the nonparametric Wilcoxon rank-sum test to the situation of whole-genome search by interval mapping. We determine the appropriate significance level for the statistic ZW, by showing that its asymptotic null distribution follows an Ornstein-Uhlenbeck process. These results provide a robust, distribution-free method for mapping QTLs.

Citing Articles

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QTL mapping of resistance to Pseudoperonospora cubensis clade 1, mating type A2, in Cucumis melo.

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Evaluating and Mapping Grape Color Using Image-Based Phenotyping.

Underhill A, Hirsch C, Clark M Plant Phenomics. 2020; 2020:8086309.

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Branham S, Daley J, Levi A, Hassell R, Wechter W Front Plant Sci. 2020; 11:1097.

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