Serum Induction of MEF2/RSRF Expression in Vascular Myocytes is Mediated at the Level of Translation

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1995 Jun 1

PMID 7760838

Citations 14

Authors

E Suzuki

K Guo

M Kolman

Y T Yu

K Walsh

Affiliations

Soon will be listed here.

Abstract

Vascular smooth muscle cells (VSMCs) reversibly coordinate the expression of VSMC-specific genes and the genes required for cell cycle progression. Here we demonstrate that isoforms of the MEF2/RSRF transcription factor are expressed in VSMCs and in vascular tissue. The MEF2A DNA-binding activity was upregulated when quiescent VSMCs were stimulated to proliferate with serum mitogens. The serum-induction of MEF2A DNA-binding activity occurred approximately 4 h following serum activation, and this correlated with an increase in the level of MEF2A protein without changes in the level of MEF2A mRNA or protein stability. These results indicate that MEF2A induction by serum is regulated at the level of translation.

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