Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida Albicans

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1976 Apr 1

PMID 773298

Citations 11

Authors

S M Hammond

B N Kliger

Affiliations

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Abstract

The polyene antibiotic candicidin produces a rapid efflux of K(+) ions from a suspension of Candida albicans. Onset of K(+) leakage depends on the culture age, stationary-phase yeasts leaking K(+) more slowly than exponential-phase yeasts. The time taken for potassium leakage to begin represents the time taken by the antibiotic to cross the cell wall and produce membrane damage. It was shown that there were factors in the cell wall of C. albicans that increased their total binding capacity and their affinity for candicidin during growth. An attempt was made to relate changes in the lipid content of the yeast cell with the increased time taken to produce membrane damage.

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Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rot by Streptomyces albidoflavus W68.

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Assessment of herbal drugs for promising anti-Candida activity.

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