» Articles » PMID: 7720072

Hemostatic, Inflammatory, and Fibroblast Responses Are Blunted in Mice Lacking Gelsolin

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 1995 Apr 7
PMID 7720072
Citations 141
Authors
Affiliations
Soon will be listed here.
Abstract

Gelsolin, an 82 kDa actin-binding protein, has potent actin filament-severing activity in vitro. To investigate the in vivo function of gelsolin, transgenic gelsolin-null (Gsn-) mice were generated and found to have normal embryonic development and longevity. However, platelet shape changes are decreased in Gsn- mice, causing prolonged bleeding times. Neutrophil migration in vivo into peritoneal exudates and in vitro is delayed. Gsn- dermal fibroblasts have excessive actin stress fibers and migrate more slowly than wild-type fibroblasts, but have increased contractility in vitro. These observations establish the requirement of gelsolin for rapid motile responses in cell types involved in stress responses such as hemostasis, inflammation, and wound healing. Neither gelsolin nor other proteins with similar actin filament-severing activity are expressed in early embryonic cells, indicating that this mechanism of actin filament dynamics is not essential for motility during early embryogenesis.

Citing Articles

Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation.

Wang X, Fu M, Wang W, Shu S, Zhang N, Zhao R BMC Med. 2024; 22(1):595.

PMID: 39707349 PMC: 11662534. DOI: 10.1186/s12916-024-03791-4.


Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics.

Akula S, Alvarado-Vazquez A, Haide Mendez Enriquez E, Bal G, Franke K, Wernersson S Int J Mol Sci. 2024; 25(23).

PMID: 39684762 PMC: 11642334. DOI: 10.3390/ijms252313050.


The therapeutic potential of gelsolin in attenuating cytokine storm, ARDS, and ALI in severe COVID-19.

Zhi J, Zhao K, Liu J, Yang D, Deng X, Xu J Front Pharmacol. 2024; 15:1447403.

PMID: 39130641 PMC: 11310015. DOI: 10.3389/fphar.2024.1447403.


Cytoskeleton-associated gelsolin responds to the midgut distention process in saline meal-fed Aedes aegypti and affects arbovirus dissemination from the midgut.

Cui Y, Megawati D, Lin J, Rehard D, Grant D, Liu P FASEB J. 2024; 38(14):e23764.

PMID: 39042395 PMC: 11268798. DOI: 10.1096/fj.202302684RR.


The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation.

Nakamura F Int J Mol Sci. 2024; 25(4).

PMID: 38396812 PMC: 10889191. DOI: 10.3390/ijms25042135.