The Role of Cytokines in the Immunopathogenesis of Lupus

Overview

Journal Springer Semin Immunopathol

Specialty Allergy & Immunology

Date 1994 Jan 1

PMID 7716703

Citations 13

Authors

B S Handwerger

V Rus

L da Silva

C S Via

Affiliations

Soon will be listed here.

Citing Articles

Cardiovascular changes in the NZB/W F1 mouse model of lupus nephritis.

Bohme R, Daniel C, Ferrazzi F, Angeloni M, Ekici A, Winkler T Front Cardiovasc Med. 2023; 10:1182193.

PMID: 37554366 PMC: 10405627. DOI: 10.3389/fcvm.2023.1182193.

Down-regulated NOD2 by immunosuppressants in peripheral blood cells in patients with SLE reduces the muramyl dipeptide-induced IL-10 production.

Yu S, Wong C, Wong P, Chen D, Szeto C, Li E PLoS One. 2011; 6(8):e23855.

PMID: 21886831 PMC: 3158772. DOI: 10.1371/journal.pone.0023855.

Defective in vitro IL-2 production in lupus is an early but secondary event paralleling disease activity: evidence from the murine parent-into-F1 model supports staging of IL-2 defects in human lupus.

Via C, Shearer G Autoimmunity. 2009; 43(1):23-31.

PMID: 20001649 PMC: 3215295. DOI: 10.3109/08916930903374808.

Tumour necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) and their soluble receptors (sTNF-alpha-Rp55 and slL-6R) serum levels in systemic lupus erythematodes.

Robak E, Sysa-Jedrzejowska A, Robak T, Stepien H, Wozniacka A, Waszczykowsk E Mediators Inflamm. 1996; 5(6):435-41.

PMID: 18475749 PMC: 2365820. DOI: 10.1155/S0962935196000609.

A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation.

Luger D, Dayan M, Zinger H, Liu J, Mozes E J Clin Immunol. 2004; 24(6):579-90.

PMID: 15622442 DOI: 10.1007/s10875-004-6245-2.

References

Kobayashi I, Matsuda T, Saito T, Yasukawa K, Kikutani H, Hirano T . Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells. Int Immunol. 1992; 4(12):1407-12. DOI: 10.1093/intimm/4.12.1407. View

ELKINS W . Cellular immunology and the pathogenesis of graft versus host reactions. Prog Allergy. 1971; 15:78-187. View

Pelton B, DENMAN A . Spontaneous production of B cell growth factors by SLE lymphocytes. Clin Exp Immunol. 1987; 67(1):159-66. PMC: 1542552. View

Steinberg A, Roths J, MURPHY E, Steinberg R, Raveche E . Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice. J Immunol. 1980; 125(2):871-3. View

Tanaka Y, Saito K, Shirakawa F, Ota T, Suzuki H, Eto S . Production of B cell-stimulating factors by B cells in patients with systemic lupus erythematosus. J Immunol. 1988; 141(9):3043-9. View

Draeger A, Swaak A, van den Brink H, Aarden L . T cell function in systemic lupus erythematosus: normal production of and responsiveness to interleukin 2. Clin Exp Immunol. 1986; 64(1):80-7. PMC: 1542159. View

Campen D, Horwitz D, Quismorio Jr F, Ehresmann G, Martin W . Serum levels of interleukin-2 receptor and activity of rheumatic diseases characterized by immune system activation. Arthritis Rheum. 1988; 31(11):1358-64. DOI: 10.1002/art.1780311103. View

Semenzato G, Bambara L, Biasi D, Frigo A, Vinante F, Zuppini B . Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis. J Clin Immunol. 1988; 8(6):447-52. DOI: 10.1007/BF00916949. View

Gaspar M, Alvarez-Mon M, Gutierrez C . The B-cell activation pathway in human systemic lupus erythematosus: imbalanced in vitro production of lymphokines and association with serum analytical findings. J Clin Immunol. 1988; 8(4):266-74. DOI: 10.1007/BF00916555. View

10.

Gillis S, Mochizuki D, Conlon P, Hefeneider S, Ramthun C, Gillis A . Molecular characterization of interleukin 2. Immunol Rev. 1982; 63:167-209. DOI: 10.1111/j.1600-065x.1982.tb00415.x. View

11.

Shaw J, Caplan B, Paetkau V, Pilarski L, Delovitch T, McKenzie I . Cellular origins of co-stimulator (IL2) and its activity in cytotoxic T lymphocyte responses. J Immunol. 1980; 124(5):2231-9. View

12.

Tanaka Y, Saito K, Suzuki H, Eto S, Yamashita U . Inhibitory effect of anti-class II antibody on the spontaneous activation of B cells in patients with systemic lupus erythematosus. Analysis with IL-1 production and IL-1 receptor expression. J Immunol. 1989; 143(5):1584-90. View

13.

Jira M, Strejcek J, Zavadil Z, Antosova E, REJHOLEC V . Interleukin-2 activated cells from peripheral blood of patients with systemic lupus erythematosus. Z Rheumatol. 1990; 49(1):30-3. View

14.

Hirose T, Hara M, Kitani A, Hirose W, Norioka K, Kawagoe M . Abnormal production of and response to B-cell growth factor and B-cell differentiation factor in patients with systemic lupus erythematosus. Scand J Immunol. 1985; 21(2):141-50. DOI: 10.1111/j.1365-3083.1985.tb01413.x. View

15.

Ueda Y, Sakane T, Tsunematsu T . Hyperreactivity of activated B cells to B cell growth factor in patients with systemic lupus erythematosus. J Immunol. 1989; 143(12):3988-93. View

16.

Ehrenstein M, McSweeney E, Swane M, Worman C, Goldstone A, Isenberg D . Appearance of anti-DNA antibodies in patients treated with interferon-alpha. Arthritis Rheum. 1993; 36(2):279-80. DOI: 10.1002/art.1780360224. View

17.

Umland S, Go N, Cupp J, Howard M . Responses of B cells from autoimmune mice to IL-5. J Immunol. 1989; 142(5):1528-35. View

18.

Davignon J, Cohen P, Eisenberg R . Immunological effects of recombinant interferon gamma in vivo in normal mice: failure to induce autoantibodies. Int J Immunopharmacol. 1990; 12(6):691-8. DOI: 10.1016/0192-0561(90)90107-x. View

19.

Reem G, Yeh N, Urdal D, Kilian P, Farrar J . Induction and upregulation by interleukin 2 of high-affinity interleukin 2 receptors on thymocytes and T cells. Proc Natl Acad Sci U S A. 1985; 82(24):8663-6. PMC: 391496. DOI: 10.1073/pnas.82.24.8663. View

20.

Flescher E, Fossum D, Ballester A, Maizel A, Sharma S, Talal N . Characterization of B cell growth in systemic lupus erythematosus. Effects of recombinant 12-kDa B cell growth factor, interleukin 4 and transforming growth factor-beta. Eur J Immunol. 1990; 20(11):2425-30. DOI: 10.1002/eji.1830201110. View