Estimation of SLE Activity Based on the Serum Level of Chosen Cytokines and Superoxide Radical Generation

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2000 Mar 7

PMID 10704146

Citations 11

Authors

E Waszczykowska

E Robak

A Wozniacka

J Narbutt

J D Torzecka

A Sysa-Jedrzejowska

Affiliations

Soon will be listed here.

Abstract

We estimated the serum levels of IL-6, TNF-alpha and IL-10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.

Citing Articles

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