Structural Implications of the Substitution of Val for Met at Residue 239 in the Alpha Chain of Human Platelet Glycoprotein Ib

Overview

Journal J Protein Chem

Specialties Biochemistry
Chemistry

Date 1994 Oct 1

PMID 7702744

Authors

M R Pincus

R P Carty

J L Miller

Affiliations

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References

Miller J, Ruggeri Z, Lyle V . Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease. Blood. 1987; 70(6):1804-9. View

Pincus M, Dykes D, Carty R, Miller J . Conformational energy analysis of the substitution of Val for Gly 233 in a functional region of platelet GPIb alpha in platelet-type von Willebrand disease. Biochim Biophys Acta. 1991; 1097(2):133-9. DOI: 10.1016/0925-4439(91)90097-s. View

Pincus M, Brandt-Rauf P, Carty R, Lubowsky J, Avitable M, Gibson K . Conformational effects of substituting amino acids for glutamine-61 on the central transforming region of the P21 proteins. Proc Natl Acad Sci U S A. 1987; 84(23):8375-9. PMC: 299545. DOI: 10.1073/pnas.84.23.8375. View

Miller J, Castella A . Platelet-type von Willebrand's disease: characterization of a new bleeding disorder. Blood. 1982; 60(3):790-4. View

Miller J, Cunningham D, Lyle V, Finch C . Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease. Proc Natl Acad Sci U S A. 1991; 88(11):4761-5. PMC: 51746. DOI: 10.1073/pnas.88.11.4761. View

Weiss H, Meyer D, Rabinowitz R, Pietu G, Girma J, Vicic W . Pseudo-von Willebrand's disease. An intrinsic platelet defect with aggregation by unmodified human factor VIII/von Willebrand factor and enhanced adsorption of its high-molecular-weight multimers. N Engl J Med. 1982; 306(6):326-33. DOI: 10.1056/NEJM198202113060603. View

Murata M, Russell S, Ruggeri Z, Ware J . Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment. J Clin Invest. 1993; 91(5):2133-7. PMC: 288214. DOI: 10.1172/JCI116438. View

Zimmerman S, Pottle M, NEMETHY G, Scheraga H . Conformational analysis of the 20 naturally occurring amino acid residues using ECEPP. Macromolecules. 1977; 10(1):1-9. DOI: 10.1021/ma60055a001. View

Miller J, Kupinski J, Castella A, Ruggeri Z . von Willebrand factor binds to platelets and induces aggregation in platelet-type but not type IIB von Willebrand disease. J Clin Invest. 1983; 72(5):1532-42. PMC: 370441. DOI: 10.1172/JCI111112. View

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Russell S, Roth G . Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor. Blood. 1993; 81(7):1787-91. View

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Takahashi H . Studies on the pathophysiology and treatment of von Willebrand's disease. IV. Mechanism of increased ristocetin-induced platelet aggregation in von Willebrand's disease. Thromb Res. 1980; 19(6):857-67. DOI: 10.1016/0049-3848(80)90013-4. View