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In Vivo and in Vitro Expression of Canine Distemper Viral Proteins in Dogs and Non-domestic Carnivores

Overview
Journal Arch Virol
Specialty Microbiology
Date 1993 Jan 1
PMID 7691048
Citations 6
Authors
S Alldinger
W Baumgartner
P Van Moll
C Orvell
Affiliations
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Abstract

The occurrence of the nucleo-, phospho-, matrix, fusion, and hemagglutinin proteins of the canine distemper virus (CDV) was investigated immunocytochemically in the brains of 3 dogs, 6 stone martens, 1 polecat, and 1 weasel. In addition, viral protein expression was studied in primary brain cell cultures of the 3 dogs after co-cultivation with Vero cells. Immunohistochemically, only minor differences, restricted to the H-4 epitope, were noted between the various species and CDV isolates. The data presented indicate that the mustelid virus is antigenically not distinct from the canine morbillivirus.

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