Receptor Interactions in a Signalling System: Competition Between Ribose Receptor and Galactose Receptor in the Chemotaxis Response

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1976 Mar 1

PMID 768985

Citations 31

Authors

P G Strange

D E Koshland Jr

Affiliations

Soon will be listed here.

Abstract

Galactose and ribose receptors are shown to compete for a common site by comparing the specificities of the purified receptors with the specificity of the whole organism response. Ribose does not bind to the purified galactose receptor but inhibits the in vivo galactose response. A mutant lacking the ribose receptor shows no inhibition of the galactose response even at very high ribose concentrations. The results can be explained by a mechanism involving (a) a ligand-induced conformational change in the receptor which produces a combining site with affinity for the molecule that serves as a first component of the signalling system and (b) a limited number of such first component molecules that cannot bind both receptors simultaneously. The mechanism may have considerable generality for sensory, hormonal, and transport systems.

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