Metronidazole in Prevention and Treatment of Bacteroides Infections After Appendicectomy

Overview

Journal Br Med J

Specialty General Medicine

Date 1976 Feb 7

PMID 764935

Citations 35

Authors

A T Willis

I R FERGUSON

P H Jones

K D Phillips

P V Tearle

R B Berry

R V FIDDIAN

D F Graham

D H HARLAND

D B Innes

W M Mee

R L ROTHWELL-JACKSON

I Sutch

C Kilbey

D Edwards

Affiliations

Soon will be listed here.

Abstract

The frequency of non-clostridial anaerobic infection was studied in 95 patients who had undergone acute appendicectomy: 49 received prophylactic metronidazole and 46 received placebo. Anaerobic infection did not develop in any of the metronidazole-treated patients, but infections did develop in nine (19%) of the 46 controls. Metronidazole is conveniently administered by suppository to patients who cannot take oral drugs. Five patients with intra-abdominal infections caused by non-clostridial anaerobes were successfully treated with metronidazole.

Citing Articles

Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis.

Veeranagouda Y, Husain F, Boente R, Moore J, Jeffrey Smith C, Rocha E J Antimicrob Chemother. 2014; 69(10):2634-43.

PMID: 25028451 PMC: 4164142. DOI: 10.1093/jac/dku219.

Lack of benefit of preoperative antimicrobial prophylaxis in children with acute appendicitis: a prospective cohort study.

Bansal V, Altermatt S, Nadal D, Berger C Infection. 2012; 40(6):635-41.

PMID: 22810888 DOI: 10.1007/s15010-012-0297-7.

Oral metronidazole as antibiotic prophylaxis for patients with nonperforated appendicitis.

Ravari H, Jangjoo A, Motamedifar J, Moazzami K Clin Exp Gastroenterol. 2012; 4:273-6.

PMID: 22235170 PMC: 3254204. DOI: 10.2147/CEG.S18153.

In vitro susceptibility to selected antibiotics in bacteria of the Bacteroides fragilis group.

Chmelar D Folia Microbiol (Praha). 2009; 54(4):353-8.

PMID: 19826924 DOI: 10.1007/s12223-009-0050-5.

The appendix stump: should it be invaginated?.

Dick J Ann R Coll Surg Engl. 2009; 66(5):379.

PMID: 19310977 PMC: 2493684.

References

Ingham H, Rich G, Selkon J, Hale J, Roxby C, BETTY M . Treatment with metronidazole of three patients with serious infections due to Bacteroides fragilis. J Antimicrob Chemother. 1975; 1(2):235-42. DOI: 10.1093/jac/1.2.235. View

Benson E, Brown G, Whittaker M . Prevention of wound infection in acute appendicitis. Lancet. 1973; 2(7824):322. DOI: 10.1016/s0140-6736(73)90822-2. View

Airan M, LEVINE H, SICE J . Prevention of wound infection. Lancet. 1973; 1(7811):1058. DOI: 10.1016/s0140-6736(73)90691-0. View

Magarey C, Chant A, Rickford C, Margarey J . Peritoneal drainage and systemic antibiotics after appendicectomy. A prospective trial. Lancet. 1971; 2(7717):179-82. DOI: 10.1016/s0140-6736(71)90894-4. View

Chow A, Marshall J, Guze L . Anaerobic infections of the female genital tract: prospects and perspectives. Obstet Gynecol Surv. 1975; 30(7):477-94. DOI: 10.1097/00006254-197507000-00028. View