Effect of Tinidazole on the Oral, Throat, and Colon Microflora of Man

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 1980 Feb 1

PMID 7382911

Citations 3

Authors

A Heimdahl

C E Nord

K Okuda

Affiliations

Soon will be listed here.

Abstract

Tinidazole in capsules was given orally in doses of 150 mg twice per day for 7 days to ten subjects. Saliva, throat, and faecal specimens were taken up to 16 days after administration for cultivation of aerobic and anaerobic bacteria and for assay of tinidazole. Mean peak serum levels of tinidazole varied between 3.3 microgram/ml to 5.4 microgram/ml. The saliva concentrations of tinidazole were between 2.9 microgram/ml to 5.9 microgram/ml. No concentration of tinidazole was detected in faeces. In saliva, a slight decrease in the numbers of fusobacteria was found, but no other changes in the oral, throat, or colon microflora were observed.

Citing Articles

Effect of erythromycin and clindamycin on the indigenous human anaerobic flora and new colonization of the gastrointestinal tract.

Heimdahl A, Nord C Eur J Clin Microbiol. 1982; 1(1):38-48.

PMID: 7173170 DOI: 10.1007/BF02014139.

Tinidazole in anaerobic infections: a review of its antibacterial activity, pharmacological properties and therapeutic efficacy.

Carmine A, Brogden R, Heel R, Speight T, Avery G Drugs. 1982; 24(2):85-117.

PMID: 6749473 DOI: 10.2165/00003495-198224020-00001.

Tinidazole--microbiology, pharmacology and efficacy in anaerobic infections.

Nord C, Kager L Infection. 1983; 11(1):54-60.

PMID: 6341253 DOI: 10.1007/BF01651361.

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