Differential Antigen Burden Modulates the Gamma Interferon but Not the Immunoglobulin Response in Mice That Vary in Susceptibility to Sendai Virus Pneumonia

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1995 Sep 1

PMID 7637005

Citations 7

Authors

X Y Mo

M SANGSTER

S Sarawar

C Coleclough

P C Doherty

Affiliations

Soon will be listed here.

Abstract

Sendai virus, a paramyxovirus which causes murine pneumonia, grew to approximately 10-fold higher titers and was cleared less rapidly from the lungs of 129/J (129) than H-2b-compatible C57BL/6J (B6) mice. The more susceptible 129 mice also made higher titers of gamma interferon (IFN-gamma) and immunoglobulin G2a (IgG2a) virus-specific antibody. Analysis with acutely irradiated (950 rads) mice and immunologically reconstituted bone marrow (BM) radiation chimeras indicated that the enhanced virus growth was a function of the radiation-resistant respiratory epithelium. Prolonged exposure to more virus in turn influenced the magnitude of IFN-gamma production, most of which was made by CD4+ T lymphocytes. Somewhat surprisingly, however, the 129 pattern of a higher virus-specific serum Ig response skewed towards IgG2a mapped to the reconstituting BM. Thus, the characteristics of the humoral response are at least partly dissociated from both the antigen load, resulting from viral replication, and the level of IFN-gamma production. Further analysis of double chimeras (B6+129 BM-->B6 recipients) confirmed that the divergent humoral immune response to Sendai virus in B6 and 129 mice is largely determined by the inherent characteristics of the lymphoid cells.

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References

Mo X, Sarawar S, Doherty P . Induction of cytokines in mice with parainfluenza pneumonia. J Virol. 1995; 69(2):1288-91. PMC: 188706. DOI: 10.1128/JVI.69.2.1288-1291.1995. View

Majlessi L, Benaroch P, Denoyelle C, Bordenave G . Role of CD4+ and CD8+ cell subsets during amplification of natural T cell activity against IgG2ab in Igha mice and during induction of IgG2ab allotype suppression in Igha/b mice. J Immunol. 1993; 151(4):1859-67. View

Hou S, Mo X, HYLAND L, Doherty P . Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins. J Virol. 1995; 69(3):1429-34. PMC: 188729. DOI: 10.1128/JVI.69.3.1429-1434.1995. View

SANGSTER M, HYLAND L, Sealy R, Coleclough C . Distinctive kinetics of the antibody-forming cell response to Sendai virus infection of mice in different anatomical compartments. Virology. 1995; 207(1):287-91. DOI: 10.1006/viro.1995.1079. View

Jones P, Ada G . Influenza virus-specific antibody-secreting cells in the murine lung during primary influenza virus infection. J Virol. 1986; 60(2):614-9. PMC: 288933. DOI: 10.1128/JVI.60.2.614-619.1986. View

Korngold R, Feldman A, RORKE L, Lublin F, Doherty P . Acute experimental allergic encephalomyelitis in radiation bone marrow chimeras between high and low susceptible strains of mice. Immunogenetics. 1986; 24(5):309-15. DOI: 10.1007/BF00395536. View

Lublin F, Knobler R, Doherty P, Korngold R . Relapsing experimental allergic encephalomyelitis in radiation bone marrow chimeras between high and low susceptible strains of mice. Clin Exp Immunol. 1986; 66(3):491-6. PMC: 1542472. View

Brownstein D . Resistance/susceptibility to lethal Sendai virus infection genetically linked to a mucociliary transport polymorphism. J Virol. 1987; 61(5):1670-1. PMC: 254152. DOI: 10.1128/JVI.61.5.1670-1671.1987. View

Portner A, Scroggs R, Metzger D . Distinct functions of antigenic sites of the HN glycoprotein of Sendai virus. Virology. 1987; 158(1):61-8. DOI: 10.1016/0042-6822(87)90238-8. View

10.

Brownstein D, Winkler S . Genetic determinants of lung virus titers and resistance to lethal Sendai virus pneumonia. Arch Virol. 1987; 96(3-4):201-14. DOI: 10.1007/BF01320960. View

11.

Breider M, Adams L, Womack J . Influence of interferon in natural resistance of mice to Sendai virus pneumonia. Am J Vet Res. 1987; 48(12):1746-50. View

12.

Finkelman F, Katona I, Mosmann T, Coffman R . IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol. 1988; 140(4):1022-7. View

13.

Mackay I, Wittingham S, Tait B . Genetic control of immune responsiveness in man. Vox Sang. 1977; 32(1):10-9. DOI: 10.1111/j.1423-0410.1977.tb00598.x. View

14.

Parker J, Whiteman M, Richter C . Susceptibility of inbred and outbred mouse strains to Sendai virus and prevalence of infection in laboratory rodents. Infect Immun. 1978; 19(1):123-30. PMC: 414057. DOI: 10.1128/iai.19.1.123-130.1978. View

15.

Brownstein D, Smith A, Johnson E . Sendai virus infection in genetically resistant and susceptible mice. Am J Pathol. 1981; 105(2):156-63. PMC: 1903884. View

16.

Dales S, Fujinami R, Oldstone M . Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin. J Immunol. 1983; 131(3):1546-53. View

17.

Nathan C, Murray H, Wiebe M, Rubin B . Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med. 1983; 158(3):670-89. PMC: 2187114. DOI: 10.1084/jem.158.3.670. View

18.

Brodeur P, Riblet R . The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. One hundred Igh-V genes comprise seven families of homologous genes. Eur J Immunol. 1984; 14(10):922-30. DOI: 10.1002/eji.1830141012. View

19.

Tashiro M, Homma M . Protection of mice from wild-type Sendai virus infection by a trypsin-resistant mutant, TR-2. J Virol. 1985; 53(1):228-34. PMC: 255018. DOI: 10.1128/JVI.53.1.228-234.1985. View

20.

Tashiro M, Seto J, Klenk H, Rott R . Possible involvement of microtubule disruption in bipolar budding of a Sendai virus mutant, F1-R, in epithelial MDCK cells. J Virol. 1993; 67(10):5902-10. PMC: 238010. DOI: 10.1128/JVI.67.10.5902-5910.1993. View