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Inhibition of Secretin Stimulated Pancreatic Secretion by Pancreatic Polypeptide

Overview
Journal Gut
Specialty Gastroenterology
Date 1979 Jan 1
PMID 761835
Citations 19
Authors
T E Adrian
H S Besterman
C N Mallinson
G R Greenberg
S R Bloom
Affiliations
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Abstract

The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than 0.0005) respectively. PP, thus, may be an important inhibitory factor in the control of bilirubin and pancreatic enzyme secretion in man.

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