Long Cytoplasmic Processes in Pancreatic Polypeptide Cells

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1980 Jan 1

PMID 6250702

Citations 3

Authors

J Rahier

J Wallon

Affiliations

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Abstract

Pancreatic polypeptide (PP) cells were studied in human endocrine pancreatic tumours and in normal human pancreata by immunohistochemical techniques and electron miscroscopy. The existence of long cytoplasmic processes was demonstrated both in tumours and normal tissue. These processes are in close contact with other endocrine cells or with acinar cells. This particular morphological aspect suggests that PP cells may control the function of other cells via paracrine secretion.

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References

Larsson L, Sundler F, Hakanson R . Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tissue Res. 1975; 156(2):167-71. DOI: 10.1007/BF00221800. View

Larsson L, Sundler F, Hakanson R . Pancreatic polypeptide - a postulated new hormone: identification of its cellular storage site by light and electron microscopic immunocytochemistry. Diabetologia. 1976; 12(3):211-26. DOI: 10.1007/BF00422088. View

GRAHAM Jr R, Karnovsky M . The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966; 14(4):291-302. DOI: 10.1177/14.4.291. View

Mayor H, Hampton J, Rosario B . A simple method for removing the resin from epoxy-embedded tissue. J Biophys Biochem Cytol. 1961; 9:909-10. PMC: 2225048. DOI: 10.1083/jcb.9.4.909. View

Adrian T, Besterman H, Mallinson C, Greenberg G, Bloom S . Inhibition of secretin stimulated pancreatic secretion by pancreatic polypeptide. Gut. 1979; 20(1):37-40. PMC: 1418966. DOI: 10.1136/gut.20.1.37. View

Nakane P . Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: a study on pituitary glands of the rat. J Histochem Cytochem. 1968; 16(9):557-60. DOI: 10.1177/16.9.557. View

Beauvillain J, Tramu G, Dubois M . Characterization by different techniques of adrenocorticotropin and gonadotropin producing cells in lerot pituitary (Eliomys quercinus). Cell Tissue Res. 1975; 158(3):301-17. DOI: 10.1007/BF00223828. View

Orci L, Baetens D, Ravazzola M, STEFAN Y, Malaisse-Lagae F . Pancreatic polypeptide and glucagon : non-random distribution in pancreatic islets. Life Sci. 1976; 19(12):1811-5. DOI: 10.1016/0024-3205(76)90112-0. View

FLOYD Jr J, FAJANS S, Pek S, CHANCE R . A newly recognized pancreatic polypeptide; plasma levels in health and disease. Recent Prog Horm Res. 1976; 33:519-70. DOI: 10.1016/b978-0-12-571133-3.50019-2. View

10.

Rahier J, Wallon J, GEPTS W, Haot J . Localization of pancreatic polypeptide cells in a limited lobe of the human neonate pancreas: remnant of the ventral primordium?. Cell Tissue Res. 1979; 200(3):359-66. DOI: 10.1007/BF00234848. View

11.

Gersell D, Gingerich R, Greider M . Regional distribution and concentration of pancreatic polypeptide in the human and canine pancreas. Diabetes. 1979; 28(1):11-5. View

12.

Larsson L, Goltermann N, De Magistris L, Rehfeld J, Schwartz T . Somatostatin cell processes as pathways for paracrine secretion. Science. 1979; 205(4413):1393-5. DOI: 10.1126/science.382360. View

13.

Paulin C, Dubois P . Immunohistochemical identification and localization of pancreatic polypeptide cells in the pancreas and gastrointestinal tract of the human fetus and adult man. Cell Tissue Res. 1978; 188(2):251-7. DOI: 10.1007/BF00222634. View

14.

STERNBERGER L, HARDY Jr P, CUCULIS J, MEYER H . The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem. 1970; 18(5):315-33. DOI: 10.1177/18.5.315. View

15.

Malaisse-Lagae F, STEFAN Y, Cox J, Perrelet A, Orci L . Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide. Diabetologia. 1979; 17(6):361-5. DOI: 10.1007/BF01236270. View

16.

Arimura A, Meyers C, Case W, Murphy W, Schally A . Suppression of somatostatin levels in the hepatic portal and systemic plasma of the rat by synthetic human pancreatic polypeptide. Biochem Biophys Res Commun. 1979; 89(3):913-8. DOI: 10.1016/0006-291x(79)91865-5. View

17.

Loren I, Alumets J, Hakanson R, Sundler F . Immunoreactive pancreatic polypeptide (PP) occurs in the central and peripheral nervous system: preliminary immunocytochemical observations. Cell Tissue Res. 1979; 200(2):179-86. DOI: 10.1007/BF00236410. View

18.

Baetens D, de Mey J, GEPTS W . Immunohistochemical and ultrastructural identification of the pancreatic polypeptide-producing cell (PP-cell) in the human pancreas. Cell Tissue Res. 1977; 185(2):239-46. DOI: 10.1007/BF00220668. View