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T Lymphocytes That Infiltrate Tumors and Atherosclerotic Plaques Produce Heparin-binding Epidermal Growth Factor-like Growth Factor and Basic Fibroblast Growth Factor: a Potential Pathologic Role

Overview

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1995 Jul 3

PMID 7604030

Citations 31

Authors

Authors

G E Peoples

S Blotnick

K Takahashi

M R Freeman

M Klagsbrun

T J Eberlein

Affiliations

Affiliations

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Abstract

Despite significant infiltration into tumors and atherosclerotic plaques, the role of T lymphocytes in these pathological conditions is still unclear. We have demonstrated that tumor-infiltrating lymphocytes (TILs) and plaque-infiltrating lymphocytes (PILs) produce heparin-binding epidermal growth factor-like growth factor (HB-EGF) and basic fibroblast growth factor (bFGF) in vitro under nonspecific conditions and in vivo in tumors by immunohistochemical staining. HB-EGF and bFGF derived from TILs and PILs directly stimulated tumor cells and vascular smooth muscle cells (SMCs) in vitro, respectively, while bFGF displayed angiogenic properties. Therefore, T cells may play a critical role in the SMC hyperplasia of atherosclerosis and support tumor progression by direct stimulation and angiogenesis.

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