Age-related Decrease of Nerve Growth Factor-like Immunoreactivity in the Basal Forebrain of Senescence-accelerated Mice

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1995 Jan 1

PMID 7572074

Citations 3

Authors

K Ohnishi

H Tomimoto

I Akiguchi

N Seriu

T Kawamata

S Nakamura

J Kimura

T Nishio

K Higuchi

M Hosokawa

Affiliations

Soon will be listed here.

Abstract

The senescence-accelerated mouse P10 (SAMP10) is a murine model of accelerated senescence characterized by the deterioration of learning and memory with advancing age. In the present study, we examined the distribution of nerve growth factor (NGF) immunohistochemically in SAMP10 mice and its control strain, SAMR1. In both strains, NGF-like immunoreactivity (NGF-IR) was observed in neurons throughout the entire forebrain and in glial cells in a particular location. In aged SAMP10 mice, each layer of the cerebral cortex retained its NGF-IR, although the thickness of the cortical mantle was markedly decreased in comparison with younger animals. There was an age-related decline in NGF-IR in the substantia innominata of SAMP10 mice at the age of 10 months, when compared to 2-month-old SAMP10. These results indicate age-related decrease of NGF in the basal forebrain in SAMP10 mice.

Citing Articles

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References

Coyle J, Price D, DeLong M . Alzheimer's disease: a disorder of cortical cholinergic innervation. Science. 1983; 219(4589):1184-90. DOI: 10.1126/science.6338589. View

Gnahn H, Hefti F, Heumann R, Schwab M, Thoenen H . NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: evidence for a physiological role of NGF in the brain?. Brain Res. 1983; 285(1):45-52. DOI: 10.1016/0165-3806(83)90107-4. View

Naiki H, Higuchi K, Matsushima K, Shimada A, Chen W, Hosokawa M . Fluorometric examination of tissue amyloid fibrils in murine senile amyloidosis: use of the fluorescent indicator, thioflavine T. Lab Invest. 1990; 62(6):768-73. View

Shimada A, Ohta A, Akiguchi I, Takeda T . Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. J Neuropathol Exp Neurol. 1992; 51(4):440-50. DOI: 10.1097/00005072-199207000-00006. View

Matsushita M, Tsuboyama T, Kasai R, Okumura H, Yamamuro T, Higuchi K . Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am J Pathol. 1986; 125(2):276-83. PMC: 1888250. View

Levi-Montalcini R, ANGELETTI P . Second symposium on catecholamines. Modification of sympathetic function. Immunosympathectomy. Pharmacol Rev. 1966; 18(1):619-28. View

Ayer-Lelievre C, Olson L, Ebendal T, Seiger A, Persson H . Expression of the beta-nerve growth factor gene in hippocampal neurons. Science. 1988; 240(4857):1339-41. DOI: 10.1126/science.2897715. View

Lu B, Yokoyama M, Dreyfus C, Black I . NGF gene expression in actively growing brain glia. J Neurosci. 1991; 11(2):318-26. PMC: 6575219. View

Hosokawa M, Ashida Y, Tsuboyama T, Chen W, Takeda T . Cataract in senescence accelerated mouse (SAM). 2. Development of a new strain of mouse with late-appearing cataract. Exp Eye Res. 1988; 47(4):629-40. DOI: 10.1016/0014-4835(88)90100-5. View

10.

Nishio T, Furukawa S, Akiguchi I, Oka N, Ohnishi K, Tomimoto H . Cellular localization of nerve growth factor-like immunoreactivity in adult rat brain: quantitative and immunohistochemical study. Neuroscience. 1994; 60(1):67-84. DOI: 10.1016/0306-4522(94)90204-6. View

11.

Miyamoto M, Shintani M, Nagaoka A, Nagawa Y . Lesioning of the rat basal forebrain leads to memory impairments in passive and active avoidance tasks. Brain Res. 1985; 328(1):97-104. DOI: 10.1016/0006-8993(85)91327-7. View

12.

Fischer W, Bjorklund A, Chen K, Gage F . NGF improves spatial memory in aged rodents as a function of age. J Neurosci. 1991; 11(7):1889-906. PMC: 6575486. View

13.

Gall C, Isackson P . Limbic seizures increase neuronal production of messenger RNA for nerve growth factor. Science. 1989; 245(4919):758-61. DOI: 10.1126/science.2549634. View

14.

Lu B, Buck C, Dreyfus C, Black I . Expression of NGF and NGF receptor mRNAs in the developing brain: evidence for local delivery and action of NGF. Exp Neurol. 1989; 104(3):191-9. DOI: 10.1016/0014-4886(89)90029-0. View

15.

Gaffan D, Murray E . Amygdalar interaction with the mediodorsal nucleus of the thalamus and the ventromedial prefrontal cortex in stimulus-reward associative learning in the monkey. J Neurosci. 1990; 10(11):3479-93. PMC: 6570092. View

16.

Furukawa S, Furukawa Y, SATOYOSHI E, Hayashi K . Synthesis and secretion of nerve growth factor by mouse astroglial cells in culture. Biochem Biophys Res Commun. 1986; 136(1):57-63. DOI: 10.1016/0006-291x(86)90876-4. View

17.

Takeda T, Hosokawa M, Higuchi K . Senescence-accelerated mouse (SAM): a novel murine model of accelerated senescence. J Am Geriatr Soc. 1991; 39(9):911-9. DOI: 10.1111/j.1532-5415.1991.tb04460.x. View

18.

Koh S, Loy R . Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons. Brain Res. 1988; 440(2):396-401. DOI: 10.1016/0006-8993(88)91015-3. View

19.

Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T . A new murine model of accelerated senescence. Mech Ageing Dev. 1981; 17(2):183-94. DOI: 10.1016/0047-6374(81)90084-1. View

20.

Nishio T, Akiguchi I, Furukawa S . Detailed distribution of nerve growth factor in rat brain determined by a highly sensitive enzyme immunoassay. Exp Neurol. 1992; 116(1):76-84. DOI: 10.1016/0014-4886(92)90178-s. View