A YAC Contig Map of the Human Genome

Overview

Journal Nature

Specialty Science

Date 1995 Sep 28

PMID 7566096

Citations 56

Authors

I M Chumakov

P Rigault

I Le Gall

C Bellanne-Chantelot

A Billault

S Guillou

P Soularue

G Guasconi

E Poullier

I Gros

Affiliations

Soon will be listed here.

Abstract

A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by several different procedures for detecting overlaps and positional information. We developed an analysis strategy that resulted, after confirmatory tests, in a YAC contig map reliably covering about 75% of the human genome in 225 contigs having an average size of about ten megabases.

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