Reproductive Factors and Colon Cancer: the Influences of Age, Tumor Site, and Family History on Risk (Utah, United States)

Overview

Journal Cancer Causes Control

Specialties Oncology
Public Health

Date 1995 Jul 1

PMID 7548720

Citations 9

Authors

M L Slattery

G P Mineau

R A Kerber

Affiliations

Soon will be listed here.

Abstract

The Utah (United States) Population Database was used to evaluate the associations between reproductive factors and colon cancer risk and the impact that family history, age at diagnosis, and tumor site have on these associations. From the cohort of (White) women in the database, all first-primary cases of colon cancer (n = 819) and controls who had complete fertility information (n = 3,202) were examined. The majority of tumors (68.6 percent) among women diagnosed at age 64 years or less were in the distal segment of the colon, while among women 65 or older, the majority of tumors (55.7 percent) were proximal. Women diagnosed before age 65 had a lower risk of colon cancer with increasing numbers of liveborn children (odds ratio [OR] = 0.6, 95 percent confidence interval [CI] = 0.3-0.9 for women with five or more children compared with women with one or two children). A long interval between first and second births (first birth-interval) was associated with increased risk of tumors in the distal segment of the colon (OR = 1.4, CI = 1.0-2.0) and among women diagnosed before age 65 (OR = 1.6, CI = 1.0-2.5); a longer, average birth-interval was associated with increased risk of proximal tumors (OR = 1.5, CI = 1.1-2.1).(ABSTRACT TRUNCATED AT 250 WORDS)

Citing Articles

Age at menarche and risk of colorectal cancer: a meta-analysis.

Li C, Song B, Wang Y, Meng H, Guo S, Liu L PLoS One. 2013; 8(6):e65645.

PMID: 23762403 PMC: 3675201. DOI: 10.1371/journal.pone.0065645.

Lifestyle, occupational, and reproductive factors and risk of colorectal cancer.

Lo A, Soliman A, Khaled H, Aboelyazid A, Greenson J Dis Colon Rectum. 2010; 53(5):830-7.

PMID: 20389219 PMC: 3223860. DOI: 10.1007/DCR.0b013e3181d320b1.

The relationship between gravidity and parity and colorectal cancer risk.

Wernli K, Wang Y, Zheng Y, Potter J, Newcomb P J Womens Health (Larchmt). 2009; 18(7):995-1001.

PMID: 19575687 PMC: 2851134. DOI: 10.1089/jwh.2008.1068.

A comparison of colon and rectal somatic DNA alterations.

Slattery M, Curtin K, Wolff R, Boucher K, Sweeney C, Edwards S Dis Colon Rectum. 2009; 52(7):1304-11.

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A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study.

Tamakoshi K, Wakai K, Kojima M, Watanabe Y, Hayakawa N, Toyoshima H Cancer Sci. 2004; 95(7):602-7.

PMID: 15245598 PMC: 11158833. DOI: 10.1111/j.1349-7006.2004.tb02494.x.

References

Slattery M, Kerber R . Family history of cancer and colon cancer risk: the Utah Population Database. J Natl Cancer Inst. 1994; 86(21):1618-26. DOI: 10.1093/jnci/86.21.1618. View

KWA H, CLETON F, Bulbrook R, Wang D, HAYWARD J . Plasma prolactin levels and breast cancer: relation to parity, weight and height, and age at first birth. Int J Cancer. 1981; 28(1):31-4. DOI: 10.1002/ijc.2910280106. View

Potter J, McMichael A . Large bowel cancer in women in relation to reproductive and hormonal factors: a case-control study. J Natl Cancer Inst. 1983; 71(4):703-9. View

Bufill J . Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med. 1990; 113(10):779-88. DOI: 10.7326/0003-4819-113-10-779. View

Negri E, La Vecchia C, Parazzini F, Savoldelli R, Gentile A, DAvanzo B . Reproductive and menstrual factors and risk of colorectal cancer. Cancer Res. 1989; 49(24 Pt 1):7158-61. View

Kerber R . Method for calculating risk associated with family history of a disease. Genet Epidemiol. 1995; 12(3):291-301. DOI: 10.1002/gepi.1370120306. View

Janerich D, Thompson W, Mineau G . Maternal pattern of reproduction and risk of breast cancer in daughters: results from the Utah Population Database. J Natl Cancer Inst. 1994; 86(21):1634-9. DOI: 10.1093/jnci/86.21.1634. View

Jacobs E, White E, Weiss N . Exogenous hormones, reproductive history, and colon cancer (Seattle, Washington, USA). Cancer Causes Control. 1994; 5(4):359-66. DOI: 10.1007/BF01804987. View

Berkel J, Hombergen D, Hooymayers I, Faber J . Cholecystectomy and colon cancer. Am J Gastroenterol. 1990; 85(1):61-4. View

10.

Linos D, Beard C, OFallon W, DOCKERTY M, Beart Jr R, Kurland L . Cholecystectomy and carcinoma of the colon. Lancet. 1981; 2(8243):379-81. DOI: 10.1016/s0140-6736(81)90829-1. View

11.

Chute C, Willett W, Colditz G, Stampfer M, Rosner B, Speizer F . A prospective study of reproductive history and exogenous estrogens on the risk of colorectal cancer in women. Epidemiology. 1991; 2(3):201-7. DOI: 10.1097/00001648-199105000-00007. View

12.

Davis F, Furner S, Persky V, Koch M . The influence of parity and exogenous female hormones on the risk of colorectal cancer. Int J Cancer. 1989; 43(4):587-90. DOI: 10.1002/ijc.2910430409. View

13.

Kune G, Kune S, Watson L . Children, age at first birth, and colorectal cancer risk. Data from the Melbourne Colorectal Cancer Study. Am J Epidemiol. 1989; 129(3):533-42. DOI: 10.1093/oxfordjournals.aje.a115165. View

14.

Medawar P, Hunt R . Can fetal antigens be used for prophylactic immunization?. Ciba Found Symp. 1983; 96:160-81. DOI: 10.1002/9780470720776.ch10. View

15.

McMichael A, Potter J . Host factors in carcinogenesis: certain bile-acid metabolic profiles that selectively increase the risk of proximal colon cancer. J Natl Cancer Inst. 1985; 75(2):185-91. View

16.

Cole P, MacMahon B, Brown J . Oestrogen profiles of parous and nulliparous women. Lancet. 1976; 2(7986):596-9. DOI: 10.1016/s0140-6736(76)90666-8. View

17.

Peters R, Pike M, Chang W, Mack T . Reproductive factors and colon cancers. Br J Cancer. 1990; 61(5):741-8. PMC: 1971601. DOI: 10.1038/bjc.1990.166. View

18.

Gerhardsson de Verdier M, London S . Reproductive factors, exogenous female hormones, and colorectal cancer by subsite. Cancer Causes Control. 1992; 3(4):355-60. DOI: 10.1007/BF00146889. View

19.

Plesko I, Preston-Martin S, Day N, Tzonou A, Dimitrova E, Somogyi J . Parity and cancer risk in Slovakia. Int J Cancer. 1985; 36(5):529-33. DOI: 10.1002/ijc.2910360502. View

20.

Trichopoulos D, Cole P, Brown J, Goldman M, MacMahon B . Estrogen profiles of primiparous and nulliparous women in Athens, Greece. J Natl Cancer Inst. 1980; 65(1):43-6. View