Molecular Cloning of LSIRF, a Lymphoid-specific Member of the Interferon Regulatory Factor Family That Binds the Interferon-stimulated Response Element (ISRE)

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1995 Jun 25

PMID 7541907

Citations 85

Authors

T Matsuyama

A Grossman

H W Mittrucker

D P Siderovski

F Kiefer

T Kawakami

C D Richardson

T Taniguchi

S K Yoshinaga

T W Mak

Affiliations

Soon will be listed here.

Abstract

Interferon regulatory factor (IRF) genes encode a family of DNA-binding proteins that are involved in the transcriptional regulation of type-I interferon and/or interferon-inducible genes. We report here the characterization of LSIRF, a new member of the IRF gene family cloned from mouse spleen by the polymerase chain reaction using degenerate primers. LSIRF was found to encode a 51 kDa protein that shares a high degree of amino acid sequence homology in the DNA-binding domain with other IRF family members. LSIRF expression was detectable only in lymphoid cells. In contrast to other IRF genes, LSIRF expression was not induced by interferons, but rather by antigen-receptor mediated stimuli such as plant lectins, CD3 or IgM crosslinking. In in vitro DNA binding studies, LSIRF was able to bind to the interferon-stimulated response element (ISRE) of the MHC class I promoter. The expression pattern and DNA binding activities suggest that LSIRF plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.

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References

Mirkovitch J, Decker T, Darnell Jr J . Interferon induction of gene transcription analyzed by in vivo footprinting. Mol Cell Biol. 1992; 12(1):1-9. PMC: 364063. DOI: 10.1128/mcb.12.1.1-9.1992. View

Miyamoto M, Fujita T, Kimura Y, Maruyama M, Harada H, Sudo Y . Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements. Cell. 1988; 54(6):903-13. DOI: 10.1016/s0092-8674(88)91307-4. View

Cumano A, Paige C, Iscove N, Brady G . Bipotential precursors of B cells and macrophages in murine fetal liver. Nature. 1992; 356(6370):612-5. DOI: 10.1038/356612a0. View

Nye J, Petersen J, Gunther C, Jonsen M, Graves B . Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev. 1992; 6(6):975-90. DOI: 10.1101/gad.6.6.975. View

Veals S, Schindler C, Leonard D, Fu X, Aebersold R, Darnell Jr J . Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol. 1992; 12(8):3315-24. PMC: 364572. DOI: 10.1128/mcb.12.8.3315-3324.1992. View

Schindler C, Fu X, Improta T, Aebersold R, Darnell Jr J . Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A. 1992; 89(16):7836-9. PMC: 49806. DOI: 10.1073/pnas.89.16.7836. View

Fu X, Schindler C, Improta T, Aebersold R, Darnell Jr J . The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A. 1992; 89(16):7840-3. PMC: 49807. DOI: 10.1073/pnas.89.16.7840. View

Weisz A, Marx P, Sharf R, Appella E, Driggers P, Ozato K . Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. J Biol Chem. 1992; 267(35):25589-96. View

Fujita T, Sakakibara J, Sudo Y, Miyamoto M, Kimura Y, Taniguchi T . Evidence for a nuclear factor(s), IRF-1, mediating induction and silencing properties to human IFN-beta gene regulatory elements. EMBO J. 1988; 7(11):3397-405. PMC: 454838. DOI: 10.1002/j.1460-2075.1988.tb03213.x. View

10.

Fujita T, Kimura Y, Miyamoto M, Barsoumian E, Taniguchi T . Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1. Nature. 1989; 337(6204):270-2. DOI: 10.1038/337270a0. View

11.

Lenardo M, Baltimore D . NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell. 1989; 58(2):227-9. DOI: 10.1016/0092-8674(89)90833-7. View

12.

Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A . Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 1989; 58(4):729-39. DOI: 10.1016/0092-8674(89)90107-4. View

13.

Meyer K, Neuberger M . The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region. EMBO J. 1989; 8(7):1959-64. PMC: 401057. DOI: 10.1002/j.1460-2075.1989.tb03601.x. View

14.

Risse G, Jooss K, Neuberg M, Bruller H, Muller R . Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes. EMBO J. 1989; 8(12):3825-32. PMC: 402070. DOI: 10.1002/j.1460-2075.1989.tb08560.x. View

15.

Bernardi G . The isochore organization of the human genome. Annu Rev Genet. 1989; 23:637-61. DOI: 10.1146/annurev.ge.23.120189.003225. View

16.

Klemsz M, McKercher S, Celada A, Van Beveren C, Maki R . The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell. 1990; 61(1):113-24. DOI: 10.1016/0092-8674(90)90219-5. View

17.

Levy D, Lew D, Decker T, Kessler D, Darnell Jr J . Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J. 1990; 9(4):1105-11. PMC: 551785. DOI: 10.1002/j.1460-2075.1990.tb08216.x. View

18.

Driggers P, Ennist D, Gleason S, Mak W, Marks M, Levi B . An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A. 1990; 87(10):3743-7. PMC: 53979. DOI: 10.1073/pnas.87.10.3743. View

19.

Akira S, Isshiki H, Sugita T, TANABE O, Kinoshita S, Nishio Y . A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 1990; 9(6):1897-906. PMC: 551896. DOI: 10.1002/j.1460-2075.1990.tb08316.x. View

20.

Hagman J, Rudin C, Haasch D, Chaplin D, STORB U . A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B. Genes Dev. 1990; 4(6):978-92. DOI: 10.1101/gad.4.6.978. View