Inhibitory Effects of Salmon Calcitonin on the Tail-biting and Scratching Behavior Induced by Substance P and Three Excitatory Amino Acids

Overview

Journal J Neural Transm Gen Sect

Specialties Neurology
Physiology

Date 1994 Jan 1

PMID 7531982

Citations 1

Authors

Y Maeda

K Yamada

T Hasegawa

M Iyo

S Fukui

T Nabeshima

Affiliations

Soon will be listed here.

Abstract

We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was 0.1 IU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.

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