Intrathecal Substance P Elicits a Caudally-directed Biting and Scratching Behavior in Mice

Overview

Journal Brain Res

Specialty Neurology

Date 1981 Jul 27

PMID 6167328

Citations 68

Authors

J L Hylden

G L Wilcox

Affiliations

Soon will be listed here.

Abstract

Intrathecal injection of substance P in mice elicited a dose-related biting and scratching response. Systemic but not intrathecal morphine sulfate antagonized this response. We interpret these observations to define a novel nociceptive response to intrathecal substance P.

Citing Articles

Kappa opioids inhibit spinal output neurons to suppress itch.

Sheahan T, Warwick C, Cui A, Baranger D, Perry V, Smith K Sci Adv. 2024; 10(39):eadp6038.

PMID: 39321286 PMC: 11423883. DOI: 10.1126/sciadv.adp6038.

AAV-DJ is superior to AAV9 for targeting brain and spinal cord, and de-targeting liver across multiple delivery routes in mice.

Chauhan M, Daugherty A, Khadir F, Duzenli O, Hoffman A, Tinklenberg J J Transl Med. 2024; 22(1):824.

PMID: 39237935 PMC: 11375878. DOI: 10.1186/s12967-024-05599-5.

Pain persists in mice lacking both Substance P and CGRPα signaling.

MacDonald D, Jayabalan M, Seaman J, Balaji R, Nickolls A, Chesler A bioRxiv. 2023; .

PMID: 38076807 PMC: 10705526. DOI: 10.1101/2023.11.15.567208.

Identification of a convergent spinal neuron population that encodes itch.

Sheahan T, Warwick C, Cui A, Baranger D, Perry V, Smith K bioRxiv. 2023; .

PMID: 37873278 PMC: 10592866. DOI: 10.1101/2023.09.29.560205.

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain.

Chiu-Tsun Tang P, Chung J, Liao J, Chan M, Chan A, Cheng G Sci Adv. 2022; 8(40):eabn5535.

PMID: 36206343 PMC: 9544324. DOI: 10.1126/sciadv.abn5535.