Gadolinium Inhibits Mechanoelectrical Transduction in Rabbit Carotid Baroreceptors. Implication of Stretch-activated Channels

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1994 Dec 1

PMID 7527431

Citations 15

Authors

G Hajduczok

M W Chapleau

R J Ferlic

H Z Mao

F M Abboud

Affiliations

Soon will be listed here.

Abstract

Gadolinium (Gd3+) has been shown to prevent mechanoelectrical transduction believed to be mediated through stretch-activated channels. We investigated the possible role of Gd(3+)-sensitive channels in mediating baroreceptor activity in the carotid sinus of rabbits. Baroreceptor activity induced by a ramp increase of carotid sinus pressure was reduced significantly during exposure to Gd3+. The inhibition was dose-related and reversible, and was not associated with alteration of carotid sinus wall mechanics as the pressure-strain relationship was unaffected. Veratrine triggered action potentials from single- and multiple-baroreceptor fibers when their response to pressure was inhibited by Gd3+. This suggests that the effect of Gd3+ on baroreceptors in the isolated carotid sinus was specific to their mechanical activation. The results suggest that stretch-activated ion channels sensitive to Gd3+ may be the mechanoelectrical transducers of rabbit carotid sinus baroreceptors.

Citing Articles

Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.

Suarez-Roca H, Mamoun N, Sigurdson M, Maixner W Compr Physiol. 2021; 11(2):1373-1423.

PMID: 33577130 PMC: 8480547. DOI: 10.1002/cphy.c190038.

Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes.

Tu H, Zhang D, Li Y Neurosci Bull. 2018; 35(1):98-112.

PMID: 30146675 PMC: 6357267. DOI: 10.1007/s12264-018-0274-y.

Endovascular Baroreflex Amplification for Resistant Hypertension.

van Kleef M, Bates M, Spiering W Curr Hypertens Rep. 2018; 20(5):46.

PMID: 29744599 PMC: 5942348. DOI: 10.1007/s11906-018-0840-8.

Reflex arc of the teeth clenching-induced pressor response in rats.

Shoji I, Kemuriyama T, Tandai-Hiruma M, Maruyama S, Tashiro A, Yokoe H J Physiol Sci. 2016; 68(1):89-100.

PMID: 28035645 PMC: 10717518. DOI: 10.1007/s12576-016-0513-9.

Carotid baroreflex activation therapy for resistant hypertension.

Victor R Nat Rev Cardiol. 2015; 12(8):451-63.

PMID: 26149485 DOI: 10.1038/nrcardio.2015.96.

References

WELLHONER H . The action of veratridine on the membrane potential of the crayfish stretch receptor neurone. Naunyn Schmiedebergs Arch Pharmakol. 1970; 267(2):185-8. DOI: 10.1007/BF00999401. View

Naruse K, Sokabe M . Involvement of stretch-activated ion channels in Ca2+ mobilization to mechanical stretch in endothelial cells. Am J Physiol. 1993; 264(4 Pt 1):C1037-44. DOI: 10.1152/ajpcell.1993.264.4.C1037. View

Kilian P, Schacht J . Sound stimulates labeling of polyphosphoinositides in the auditory organ of the noctuid moth. J Neurochem. 1980; 34(3):709-12. DOI: 10.1111/j.1471-4159.1980.tb11201.x. View

Edwards C, Ottoson D, Rydqvist B, Swerup C . The permeability of the transducer membrane of the crayfish stretch receptor to calcium and other divalent cations. Neuroscience. 1981; 6(7):1455-60. DOI: 10.1016/0306-4522(81)90200-1. View

Thoren P, Andresen M, Brown A . Effects of changes in extracellular ionic concentrations on aortic baroreceptors with nonmyelinated afferent fibers. Circ Res. 1982; 50(3):413-8. DOI: 10.1161/01.res.50.3.413. View

Heesch C, Miller B, Thames M, Abboud F . Effects of calcium channel blockers on isolated carotid baroreceptors and baroreflex. Am J Physiol. 1983; 245(4):H653-61. DOI: 10.1152/ajpheart.1983.245.4.H653. View

Brehm P, Kullberg R, Moody-Corbett F . Properties of non-junctional acetylcholine receptor channels on innervated muscle of Xenopus laevis. J Physiol. 1984; 350:631-48. PMC: 1199290. DOI: 10.1113/jphysiol.1984.sp015222. View

Guharay F, Sachs F . Stretch-activated single ion channel currents in tissue-cultured embryonic chick skeletal muscle. J Physiol. 1984; 352:685-701. PMC: 1193237. DOI: 10.1113/jphysiol.1984.sp015317. View

Kunze D, Andresen M, Torres L . Do calcium antagonists act directly on calcium channels to alter baroreceptor function?. J Pharmacol Exp Ther. 1986; 239(2):303-10. View

10.

Docherty R . Gadolinium selectively blocks a component of calcium current in rodent neuroblastoma x glioma hybrid (NG108-15) cells. J Physiol. 1988; 398:33-47. PMC: 1191757. DOI: 10.1113/jphysiol.1988.sp017027. View

11.

Hajduczok G, Chapleau M, Abboud F . Rheoreceptors in the carotid sinus of dog. Proc Natl Acad Sci U S A. 1988; 85(19):7399-403. PMC: 282194. DOI: 10.1073/pnas.85.19.7399. View

12.

Gustin M, Zhou X, Martinac B, Kung C . A mechanosensitive ion channel in the yeast plasma membrane. Science. 1988; 242(4879):762-5. DOI: 10.1126/science.2460920. View

13.

Ubl J, Murer H, Kolb H . Ion channels activated by osmotic and mechanical stress in membranes of opossum kidney cells. J Membr Biol. 1988; 104(3):223-32. DOI: 10.1007/BF01872324. View

14.

Yang X, Sachs F . Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science. 1989; 243(4894 Pt 1):1068-71. DOI: 10.1126/science.2466333. View

15.

Erxleben C . Stretch-activated current through single ion channels in the abdominal stretch receptor organ of the crayfish. J Gen Physiol. 1989; 94(6):1071-83. PMC: 2228948. DOI: 10.1085/jgp.94.6.1071. View

16.

Wang G, Dugas M, Armah B, Honerjager P . Sodium channel comodification with full activator reveals veratridine reaction dynamics. Mol Pharmacol. 1990; 37(2):144-8. View

17.

Andresen M, Kunze D . Ionic sensitivity of baroreceptors. Circ Res. 1987; 61(4 Pt 2):I66-71. View

18.

Barnes S, Hille B . Veratridine modifies open sodium channels. J Gen Physiol. 1988; 91(3):421-43. PMC: 2216135. DOI: 10.1085/jgp.91.3.421. View

19.

Morris C . Mechanosensitive ion channels. J Membr Biol. 1990; 113(2):93-107. DOI: 10.1007/BF01872883. View

20.

Xie P, Chapleau M, McDowell T, Hajduczok G, Abboud F . Mechanism of decreased baroreceptor activity in chronic hypertensive rabbits. Role of endogenous prostanoids. J Clin Invest. 1990; 86(2):625-30. PMC: 296770. DOI: 10.1172/JCI114754. View