Differential RNA Editing in Closely Related Introns in Oenothera Mitochondria

Overview

Journal Mol Gen Genet

Specialties Genetics
Molecular Biology

Date 1994 Apr 1

PMID 7514712

Citations 13

Authors

B Lippok

A Brennicke

B Wissinger

Affiliations

Soon will be listed here.

Abstract

Introns a/b of the nad2 gene and b/c of the nad1 gene in Oenothera mitochondria were found to be closely related. Within a scaffold of conserved sequence regions, a 48 bp sequence element covering intron domain V and flanking nucleotides is identical in both group II introns. The third nucleotide of this element is edited in the nad2, but not in the nad1 intervening sequence. The C to U editing event compensates an nad2-specific nucleotide mismatch in the stem domain IV and thus improves secondary structure stability. This differential editing event indicates that the identical upstream 2 and downstream 45 nucleotides are not sufficient to specify this editing site. Comparison of adjacent exon editing patterns in spliced and unspliced transcripts shows a higher degree of editing in processed sequences, confirming that RNA editing is a posttranscriptional process in plant mitochondria.

Citing Articles

Categorizing 161 plant (streptophyte) mitochondrial group II introns into 29 families of related paralogues finds only limited links between intron mobility and intron-borne maturases.

Zumkeller S, Knoop V BMC Ecol Evol. 2023; 23(1):5.

PMID: 36915058 PMC: 10012718. DOI: 10.1186/s12862-023-02108-y.

Convergent Evolution of Fern-Specific Mitochondrial Group II Intron atp1i361g2 and Its Ancient Source Paralogue rps3i249g2 and Independent Losses of Intron and RNA Editing among Pteridaceae.

Zumkeller S, Knoop V, Knie N Genome Biol Evol. 2016; 8(8):2505-19.

PMID: 27492234 PMC: 5010907. DOI: 10.1093/gbe/evw173.

Monilophyte mitochondrial rps1 genes carry a unique group II intron that likely originated from an ancient paralog in rpl2.

Knie N, Grewe F, Knoop V RNA. 2016; 22(9):1338-48.

PMID: 27354706 PMC: 4986890. DOI: 10.1261/rna.056572.116.

The RAD52-like protein ODB1 is required for the efficient excision of two mitochondrial introns spliced via first-step hydrolysis.

Gualberto J, Le Ret M, Beator B, Kuhn K Nucleic Acids Res. 2015; 43(13):6500-10.

PMID: 26048959 PMC: 4513849. DOI: 10.1093/nar/gkv540.

Chloroplast RNA editing going extreme: more than 3400 events of C-to-U editing in the chloroplast transcriptome of the lycophyte Selaginella uncinata.

Oldenkott B, Yamaguchi K, Tsuji-Tsukinoki S, Knie N, Knoop V RNA. 2014; 20(10):1499-506.

PMID: 25142065 PMC: 4174432. DOI: 10.1261/rna.045575.114.

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