Epstein-Barr Virus Induction of Recombinase-activating Genes RAG1 and RAG2

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1995 Dec 1

PMID 7494341

Citations 19

Authors

S K Srinivas

J W Sixbey

Affiliations

Soon will be listed here.

Abstract

In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.

Citing Articles

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Bridgewater H, Date K, ONeil J, Hu C, Arrand J, Dawson C Pathogens. 2020; 9(7).

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KSHV induces immunoglobulin rearrangements in mature B lymphocytes.

Totonchy J, Osborn J, Chadburn A, Nabiee R, Argueta L, Mikita G PLoS Pathog. 2018; 14(4):e1006967.

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Niller H, Minarovits J Pathogens. 2014; 1(1):37-51.

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A Role for RNA Viruses in the Pathogenesis of Burkitt's Lymphoma: The Need for Reappraisal.

van den Bosch C Adv Hematol. 2012; 2012:494758.

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Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.

Valentine R, Dawson C, Hu C, Shah K, Owen T, Date K Mol Cancer. 2010; 9:1.

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