Hypothalamic Lesions Stimulating Growth Hormone Cell Activity in the Goldfish

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1981 Jan 1

PMID 7471185

Citations 5

Authors

J N Fryer

Affiliations

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Abstract

The cytology of the growth-hormone (GH) cells of the goldfish pituitary were examined following electrothermic lesions of the anterior preoptic hypothalamus and telencephalon. Following lesions of the nucleus preopticus (NPO) light microscopy of the pituitary revealed a significant increase in the nuclear diameter and a degranulation of the GH cells. Lesions of the telencephalon anterior or dorsal to the NPO had no cytological effect on the GH cells. The ultrastructural appearance of the GH cells of NPO-lesioned fish was characterized by a marked degranulation of the cytoplasm and a proliferation of the rough endoplasmic reticulum indicative of enhanced secretory activity. The GH cells of the proximal pars distalis (PPD) are directly innervated by peptidergic (type A) and aminergic-like (type B) neurosecretory axons. Following lesions of the NPO, there was a marked reduction in the number of type A fibers in the PPD. These results suggest that the type A fibers innervating the GH cells originate in the NPO and act to inhibit the secretory activity of the GH cells.

Citing Articles

A light- and electron-microscopic study of goldfish corticotrops following lesions of the nucleus praeopticus.

Fryer J Cell Tissue Res. 1983; 234(1):31-8.

PMID: 6315238 DOI: 10.1007/BF00217400.

Cytological evidence for activation of neuroendocrine cells in the parvocellular preoptic nucleus of the goldfish hypothalamus following pharmacological adrenalectomy.

Fryer J Cell Tissue Res. 1981; 218(1):129-40.

PMID: 6265096 DOI: 10.1007/BF00210099.

Hypophysiotropic neurons in the goldfish hypothalamus demonstrated by retrograde transport of horseradish peroxidase.

Fryer J, Maler L Cell Tissue Res. 1981; 218(1):93-102.

PMID: 6166382 DOI: 10.1007/BF00210094.

Somatostatin in the brain and the pituitary of some teleosts. Immunocytochemical identification and the effect of starvation.

Olivereau M, Ollevier F, VANDESANDE F, Olivereau J Cell Tissue Res. 1984; 238(2):289-96.

PMID: 6150764 DOI: 10.1007/BF00217300.

Localization of growth hormone-releasing factor-like immunoreactivity in the hypothalamo-hypophysial system of some teleost species.

Olivereau M, Olivereau J, VANDESANDE F Cell Tissue Res. 1990; 259(1):73-80.

PMID: 2105165 DOI: 10.1007/BF00571432.

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