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IgM-antibody Response to the Hepatitis B Core Antigen in Acute and Chronic Hepatitis B

Overview
Journal J Hyg (Lond)
Publisher Cambridge University Press
Specialty Public Health
Date 1981 Apr 1
PMID 7462600
Citations 7
Authors
R S Tedder
Affiliations
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Abstract

A solid phase M-antibody capture radioimmunoassay (MACRIA) and a serum fractionation method were used to quantitate the IgM response to the hepatitis B core antigen (IgM anti-HBc) in acute and chronic hepatitis B infections. Antibody to the core antigen was predominantly of the IgM class during the acute phase of hepatitis B. Resolving acute infections remained positive by MACRIA, but at decreasing levels, for as long as 6 months. IgM anti-HBc persisted in HBsAg carriers but at levels very much lower than seen in acute infections. There was no correlation of IgM anti-HBc with severity of chronic liver disease in carriers. Measurement of IgM anti-HBc by MACRIA enabled accurate identification of acute hepatitis B on single serum specimens.

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References
1.
Niermeiier P, Gips C, Huizenga J, Ringers J, Verkerk S, Houthuff H . IgM-anti-HBc as a marker of persistent and IgG-anti-HBc as a marker of past hepatitis B infection. A longitudinal study over 5 years. Acta Hepatogastroenterol (Stuttg). 1978; 25(5):360-4. View
2.
Tedder R . Hepatitis B in hospitals. Br J Hosp Med. 1980; 23(3):266, 275-6, 278-9. View
3.
BRZOSKO W, Mikulska B, Cianciara J, Babiuch J . Immunoglobulin classes of antibody to hepatitis B core antigen. J Infect Dis. 1975; 132(1):1-5. DOI: 10.1093/infdis/132.1.1. View
4.
Flehmig B, Ranke M, Berthold H, GERTH H . A solid-phase radioimmunoassay for detection of IgM antibodies to hepatitis A virus. J Infect Dis. 1979; 140(2):169-75. DOI: 10.1093/infdis/140.2.169. View
5.
Gerlich W, Luer W . Selective detection of IgM-antibody against core antigen of the hepatitis B virus by a modified enzyme immune assay. J Med Virol. 1979; 4(3):227-38. DOI: 10.1002/jmv.1890040308. View