Pyrazole Prevention of CC14-induced Ultrastructural Changes in Rat Liver

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1980 Oct 1

PMID 7448119

Citations 7

Authors

A S Bernacchi

C R de Castro

E G de Toranzo

A Marzi

E C de Ferreyra

O M de Fenos

J A Castro

Affiliations

Soon will be listed here.

Abstract

Carbon tetrachloride (CC14) administration to rats leads to an early dilatation, vesiculation and disorganization of the liver endoplasmic reticulum (ER). This hepatotoxin also causes detachment of ribosomes from ER membranes, dilatation of the Golgi cisternae and occasionally dilatation of the perinuclear membrane. Prior treatment of the rats with pyrazole completely prevents CC14- induced ultrastructural alterations observed in liver at 3 h. This drug is known to decrease the intensity of the irreversible binding of CC14 reactive metabolites to cellular constituents without modifying the intensity of the CC14- induced lipid peroxidation, either in vitro or in vivo, as measured by the diene conjugation procedure or by decreases inthe arachidonic acid content of microsomal phospholipids. Results suggest that interaction of reactive metabolites rather than lipid peroxidation mediates deleterious effects of CCl4 on the liver ER.

Citing Articles

Decreased incorporation of 14C-leucine in different liver nuclear protein fractions at early stages of carbon tetrachloride poisoning in the rat.

Galelli M, Diaz Gomez M, Castro J Arch Toxicol. 1994; 68(3):206-9.

PMID: 8024469 DOI: 10.1007/s002040050056.

Effect of 3 amino 1,2,4 triazole administration on the early CCl4-induced ultrastructural alterations in rat liver.

Bernacchi A, de Castro C, de Ferreyra E, de Fenos O, Castro J Br J Exp Pathol. 1982; 63(1):35-42.

PMID: 7066182 PMC: 2040739.

Studies on the mechanism of alloxan-diabetes potentiation of carbon tetrachloride-induced liver necrosis.

Villarruel M, Fernandez G, de Ferreyra E, de Fenos O, Castro J Br J Exp Pathol. 1982; 63(4):388-93.

PMID: 6758834 PMC: 2040656.

Studies on the mechanism of glutathione prevention of carbon tetrachloride-induced liver injury.

Gorla N, de Ferreyra E, Villarruel M, de Fenos O, Castro J Br J Exp Pathol. 1983; 64(4):388-95.

PMID: 6615708 PMC: 2040791.

Carbon tetrachloride-induced liver injury in the rabbit.

Bernacchi A, de Castro C, de Ferreyra E, Villarruel M, Fernandez G, de Fenos O Br J Exp Pathol. 1983; 64(3):261-7.

PMID: 6309207 PMC: 2040671.

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