Carbon Tetrachloride-induced Early Biochemical Alterations but Not Necrosis in Pigeon's Liver

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1984 Oct 1

PMID 6098176

Authors

G Fernandez

M C Villarruel

E C de Ferreyra

O M de Fenos

A S Bernacchi

C R de Castro

J A Castro

Affiliations

Soon will be listed here.

Abstract

In contrast to what is well known to occur in rats, pigeons receiving CCl4 (1 ml/kg i.p.) were not susceptible to necrogenic effects of the hepatotoxin at 24 h. There were, however, other early biochemical alterations observable, such as depression of glucose 6 phosphatase activity, decrease in the cytochrome P-450 content and in aminopyrine-N-demethylase activity in pigeon liver microsomes at 3 and 6 h after CCl4 administration. Pigeon liver was able to activate CCl4 to reactive metabolites that bind covalently to lipids, but no CCl4-induced lipid peroxidation was proved by the diene hyperconjugation technique in pigeon liver microsomes at 1, 3 or 6 h after administration. Results suggest that covalent binding of CCl4-reactive metabolites are more relevant to early biochemical alterations induced by CCl4 than is lipid peroxidation. Absence of CCl4-induced necrosis in pigeon liver could be attributable to a smaller intensity of covalent binding interactions observed, when compared to susceptible species, and to absence of lipid peroxidation.

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