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Comparative Nephrotoxicities of High-dose Netilmicin and Tobramycin in Rats

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1980 Aug 1
PMID 7447411
Citations 6
Authors
R A Parker
D N Gilbert
D C Houghton
G A Porter
W M Bennett
Affiliations
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Abstract

The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.

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