Astrocytic Differentiation in Medulloblastoma

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1980 Nov 1

PMID 7441280

Citations 12

Authors

R O BARNARD

H Pambakian

Affiliations

Soon will be listed here.

Abstract

A case of cerebellar medulloblastoma with transitional features towards malignant fibrillary astrocytoma is described. In the cerebellum the tumour is characterised by extensive subpial infiltration with cells of undifferentiated type, and the astrocytic component could only be identified by a positive glial fibrillary acidic protein reaction. In the brainstem the character of the growth transforms to that of diffuse astrocytoma. This demonstrates the potential for differentiation existing in a "primitive" neuroepithelial neoplasm.

Citing Articles

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components.

Kuhn S, Hanisch U, Ebmeier K, Beetz C, Brodhun M, Reichart R Neurosurg Rev. 2007; 30(2):143-9.

PMID: 17333087 DOI: 10.1007/s10143-007-0069-5.

Neuropathology for the neuroradiologist: rosettes and pseudorosettes.

Wippold 2nd F, Perry A AJNR Am J Neuroradiol. 2006; 27(3):488-92.

PMID: 16551982 PMC: 7976948.

Gliosarcoma occurring 8 years after treatment for a medulloblastoma.

Malde R, Jalali R, Muzumdar D, Shet T, Kurkure P Childs Nerv Syst. 2004; 20(4):243-6.

PMID: 14704813 DOI: 10.1007/s00381-003-0850-x.

Morphological investigations on cerebellar "neuroblastoma" group.

Yagishita S, Itoh Y, Chiba Y, Kuwana N Acta Neuropathol. 1982; 56(1):22-8.

PMID: 7064656 DOI: 10.1007/BF00691178.

Divergent glial and neuronal differentiation in a cerebellar medulloblastoma in an organ culture system: in vitro occurrence of synaptic ribbons.

Herman M, Rubinstein L Acta Neuropathol. 1984; 65(1):10-24.

PMID: 6516798 DOI: 10.1007/BF00689823.

References

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