Lipomatous Differentiation in a Medulloblastoma

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1991 Jan 1

PMID 2028751

Citations 7

Authors

L Chimelli

M D Hahn

H Budka

Affiliations

Soon will be listed here.

Abstract

A surgically resected medulloblastoma of the left cerebellum in a 42-year-old man contained numerous mature fat cells; many of these adipocytes expressed glial fibrillary acidic protein (GFAP), S-100 protein, and vimentin as seen by immunocytochemistry. The cellular parts of the tumor showed varying immunoreactivities for GFAP, S-100 protein, neuron-specific enolase, and synaptophysin. It is concluded that this tumor exhibits a unique spectrum of differentiation along multiple lines, including transformation of neuroectodermal cells to fat cells. The significance of this new type of differentiation in primitive neural tumors remains to be elucidated.

Citing Articles

Understanding cerebellar liponeurocytomas: case report and literature review.

Oudrhiri M, Raouzi N, El Kacemi I, El Fatemi N, Gana R, Maaqili M Case Rep Neurol Med. 2014; 2014:186826.

PMID: 24716015 PMC: 3970250. DOI: 10.1155/2014/186826.

A 32-year-old man with a fourth ventricular mass.

Lee F, Jan Y, Wen M, Li M, Wang J, Wen-Hsien C Brain Pathol. 2009; 19(2):333-6.

PMID: 19291000 PMC: 8094765. DOI: 10.1111/j.1750-3639.2009.00276.x.

Cerebellar liponeurocytoma/lipidized medulloblastoma.

Aker F, Ozkara S, Eren P, Peker O, Armagan S, Hakan T J Neurooncol. 2005; 71(1):53-9.

PMID: 15719276 DOI: 10.1007/s11060-004-9172-4.

Genetic and expression profiles of cerebellar liponeurocytomas.

Horstmann S, Perry A, Reifenberger G, Giangaspero F, Huang H, Hara A Brain Pathol. 2004; 14(3):281-9.

PMID: 15446583 PMC: 8095792. DOI: 10.1111/j.1750-3639.2004.tb00065.x.

Ependymoma with extensive lipidization mimicking adipose tissue: a report of five cases.

Sharma M, Arora R, Lakhtakia R, Mahapatra A, Sarkar C Pathol Oncol Res. 2000; 6(2):136-40.

PMID: 10936790 DOI: 10.1007/BF03032364.

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