Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 1978 Aug 1

PMID 744100

Citations 39

Authors

W G BLACKARD

P S Guzelian

M E SMALL

Affiliations

Soon will be listed here.

Abstract

Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration of insulin in the medium in order to evoke the down regulation phenomenon.

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