Antibodies to a Human Liver Membrane Lipoprotein (LSP) in Primary Biliary Cirrhosis

Overview

Journal Gut

Specialty Gastroenterology

Date 1980 Jul 1

PMID 7429318

Citations 8

Authors

D Tsantoulas

A Perperas

B Portmann

A L Eddleston

R Williams

Affiliations

Soon will be listed here.

Abstract

Antibodies reacting with a human liver-specific membrane lipoprotein (LSP) have been detected using a sensitive and specific radioimmunoassay in 19 (51%) of 37 patients with primary biliary cirrhosis. The anti-LSP antibodies were found only in the later stages of the disease as judged by histological criteria, being present in 73% of those in stage IV, 44% of those in stage III, and none of those in stage I or II. Although there was no relationship between percentage binding and standard liver function tests, there was a close correlation between percentage binding of 125I-LSP by serum and the extent of piecemeal necrosis of periportal hepatocytes on liver biopsy. The timing of the anti-LSP response makes it very unlikely that it is involved in the pathogenesis of the early bile duct damage but the results of this and other studies suggest that antibodies to this hepatocyte membrane lipoprotein may be an important cause of periportal liver cell necrosis in both primary biliary cirrhosis and chronic active hepatitis and could be one of the factors determining progression to cirrhosis in both these conditions.

Citing Articles

Autoimmunity to a liver membrane lipoprotein and liver damage in alcoholic liver disease.

Perperas A, Tsantoulas D, Portmann B, Eddleston A, Williams R Gut. 1981; 22(2):149-52.

PMID: 7215946 PMC: 1419225. DOI: 10.1136/gut.22.2.149.

Characterization and demonstration of human liver-specific protein (LSP) and apo-LSP.

Lebwohl N, Gerber M Clin Exp Immunol. 1981; 46(2):435-42.

PMID: 6802540 PMC: 1536408.

Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B.

Meliconi R, Baraldini M, Stefanini G, Facchini A, Miglio F, Bortolotti F Clin Exp Immunol. 1981; 46(2):382-90.

PMID: 6802539 PMC: 1536384.

Studies on anti LSP autoantibodies in acute and chronic non-B hepatitis -- evidence for the lack of anti LSP in non-A, non-B (NANB) viral hepatitis.

Manns M, Arnold W, Meyer zum Buschenfelde K, NAGAI S, Hoffmann H Klin Wochenschr. 1981; 59(12):685-9.

PMID: 6789002 DOI: 10.1007/BF02593861.

Antibodies directed against human liver specific membrane lipoprotein (LSP) in marmosets experimentally infected with the hepatitis A virus.

Jensen D, Peterson D, Wolfe L, Hurley T, Payne J, Ogden J Clin Exp Immunol. 1984; 55(3):535-40.

PMID: 6705267 PMC: 1535918.

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