Hypoxanthine-arabinoside Pharmacokinetics After Adenine Arabinoside Administration to a Patient with Renal Failure

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1980 Jul 1

PMID 7416747

Citations 5

Authors

G R Aronoff

J J Szwed

R L Nelson

E L Marcus

S A Kleit

Affiliations

Soon will be listed here.

Abstract

Hypoxanthine arabinoside pharmacokinetics were measured during an adenine arabinoside continuous intravenous infusion and during hemodialysis in a patient with renal failure. Therapeutic guidelines for adenine arabinoside in renal failure are provided based on an elimination half-life of 4.7 h and a plasma clearance of 87.9 ml/min for the hypoxanthine metabolite.

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