Article: A comparison between terminally radioiodinated hexadecenoic acid (I-HA) and 201Tl-thallium chloride in the dog heart. Implications for the use of I-HA for myocardial imaging

The regional myocardial distribution of 131I-16-iodo-9-hexadecenoic acid (131I-HA) and 201Tl-thallium chloride (201TlCl) was determined in normal dogs and after occlusion of a coronary artery. The uptake of 131I-HA was about 20% lower than that of 201TlCl but the ratio 201Tl/131I was the same for the whole myocardium within narrow limits for normal as well as infarcted tissue. The potential of 123I-HA as a radiopharmaceutical for diagnosis of myocardial defects is discussed.

Citing Articles

Cardiac metabolism: a technical spectrum of modalities including positron emission tomography, single-photon emission computed tomography, and magnetic resonance spectroscopy.

Valkema R, van Eck-Smit B, van der Wall E J Nucl Cardiol. 1994; 1(6):546-60.

PMID: 9420749 DOI: 10.1007/BF02939978.

A comparison between terminally radioiodinated hexadecenoic acid (125I-HA) and heptadecanoic acid (131I-H0A) in the dog heart.

van der Wall E, Westera G, Heidendal G, den Hollander W Eur J Nucl Med. 1981; 6(12):581-4.

PMID: 7333321 DOI: 10.1007/BF00252673.

Metabolic myocardial imaging with 123I-labeled heptadecanoic acid in patients with angina pectoris.

van der Wall E, Heidendal G, den Hollander W, Westera G, ROOS J Eur J Nucl Med. 1981; 6(9):391-6.

PMID: 7274289 DOI: 10.1007/BF00266428.

Dynamic myocardial scintigraphy with 123I-labeled free fatty acids in patients with myocardial infarction.

van der Wall E, den Hollander W, Heidendal G, Westera G, Majid P, ROOS J Eur J Nucl Med. 1981; 6(9):383-9.

PMID: 7274288 DOI: 10.1007/BF00266427.

External detection of regional myocardial metabolism with radioiodinated hexadecenoic acid in the dog heart.

van der Wall E, Westera G, den Hollander W, Visser F Eur J Nucl Med. 1981; 6(4):147-51.

PMID: 7215379 DOI: 10.1007/BF00253163.

References

1.

WEGRIA R, Segers M . Relationship between the reduction in coronary flow and the appearance of electrocardiographic changes. Am Heart J. 1949; 38(1):90-6. DOI: 10.1016/0002-8703(49)90795-4. View

2.

POE N, Robinson Jr G, Zielinski F, Cabeen Jr W, Smith J, Gomes A . Myocardial imaging with 123I-hexadecenoic acid. Radiology. 1977; 124(2):419-24. DOI: 10.1148/124.2.419. View

3.

BONTE F, Graham K, Moore J . Experimental myocardial imaging with 131 I-labeled oleic acid. Radiology. 1973; 108(1):195-6. DOI: 10.1148/108.1.195. View

4.

Gunton R, Evans J, Baker R, SPEARS J, BEANLANDS D . Demonstration of myocardial infarction by photoscans of the heart in man. Am J Cardiol. 1965; 16(4):482-7. DOI: 10.1016/0002-9149(65)90023-8. View

5.

POE N, Robinson Jr G, Graham L, MACDONALD N . Experimental basis of myocardial imaging with 123I-labeled hexadecenoic acid. J Nucl Med. 1976; 17(12):1077-82. View

6.

Robinson Jr G . Synthesis of 123I-16-iodo-9-hexadecenoic acid and derivatives for use as myocardial perfusion imaging agents. Int J Appl Radiat Isot. 1977; 28(1-2):149-56. DOI: 10.1016/0020-708x(77)90168-5. View

7.

Strauss H, Harrison K, LANGAN J, Lebowitz E, Pitt B . Thallium-201 for myocardial imaging. Relation of thallium-201 to regional myocardial perfusion. Circulation. 1975; 51(4):641-5. DOI: 10.1161/01.cir.51.4.641. View

8.

Machulla H, Stocklin G, Kupfernagel C, Freundlieb C, Hock A, Vyska K . Comparative evaluation of fatty acids labeled with C-11, Cl-34m, Br-77, and I-123 for metabolic studies of the myocardium: concise communication. J Nucl Med. 1978; 19(3):298-302. View

9.

Marcus M, Kerber R, Erhardt J, Falsetti H, Davis D, Abboud F . Spatial and temporal heterogeneity of left ventricular perfusion in awake dogs. Am Heart J. 1977; 94(6):748-54. DOI: 10.1016/s0002-8703(77)80216-0. View

10.

Robinson Jr G, Lee A . Radioiodinated fatty acids for heart imaging: iodine monochloride addition compared with iodide replacement labeling. J Nucl Med. 1975; 16(1):17-21. View

11.

UTLEY J, Carlson E, Hoffman J, Martinez H, Buckberg G . Total and regional myocardial blood flow measurements with 25 micron, 15 micron, 9 micron, and filtered 1-10 micron diameter microspheres and antipyrine in dogs and sheep. Circ Res. 1974; 34(3):391-405. DOI: 10.1161/01.res.34.3.391. View

A Comparison Between Terminally Radioiodinated Hexadecenoic Acid (I-HA) and 201Tl-thallium Chloride in the Dog Heart. Implications for the Use of I-HA for Myocardial Imaging