A Comparison Between Terminally Radioiodinated Hexadecenoic Acid (125I-HA) and Heptadecanoic Acid (131I-H0A) in the Dog Heart

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1981 Dec 1

PMID 7333321

Citations 2

Authors

E E van der Wall

G Westera

G A Heidendal

W den Hollander

Affiliations

Soon will be listed here.

Abstract

The regional myocardial distribution of 125I-16-iodo-9-hexadecenoic acid (125I-HA) and 131I-17-iodo-heptadecanoic acid (131I-H0A) was determined in one normal dog and in five dogs within 5 min after coronary artery occlusion. The total myocardial uptake of 125I-H A was about 40% lower than that of 131I-H0A. The ratio 125I:131I in the normally perfused parts of the myocardium was 0.38-0.81, but the ischemic tissue showed a higher 125I:131I ratio (0.87-1.03), due to lower accumulation of 131I-H0A in ischemic myocardium. We conclude that both radioiodinated fatty acids are reliable indicators of myocardial perfusion and that iodo-heptadecanoic acid, when labeled with 123I, may be preferred to iodo-hexadecenoic acid as the labeled fatty acid for cardiac imaging agent in clinical practice.

Citing Articles

Cardiac metabolism: a technical spectrum of modalities including positron emission tomography, single-photon emission computed tomography, and magnetic resonance spectroscopy.

Valkema R, van Eck-Smit B, van der Wall E J Nucl Cardiol. 1994; 1(6):546-60.

PMID: 9420749 DOI: 10.1007/BF02939978.

Influence of propranolol on uptake of radioiodinated heptadecanoic acid and thallium-201 in the dog heart.

van der Wall E, Westera G, van Eenige M, Scholtalbers S, Visser F, den Hollander W Eur J Nucl Med. 1983; 8(10):454-7.

PMID: 6653603 DOI: 10.1007/BF00252946.

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